Practical Approaches to the Use of Markers of Biochemical Hyperandrogenism in Women

    May 2022 in “ Reproductive Endocrinology ”
    T.M. Tutchenko, О. А. Бурка, І. В. Сідорова, I.H. Nohovska, I.M. Marynchyna, N.M. Shcherbatiei
    TLDR Accurate diagnosis and treatment of hyperandrogenism in women require comprehensive evaluation of symptoms and hormone levels.
    The document reviewed practical approaches to using markers of biochemical hyperandrogenism (HA) in women, focusing on the discrepancy between clinical signs and biochemical parameters. It analyzed androgen synthesis and metabolism in healthy women and the management of HA-related pathologies. The review highlighted the importance of differentiating between clinical HA, characterized by hirsutism, and biochemical HA, marked by elevated androgen levels. Common causes of HA included polycystic ovary syndrome and congenital adrenal hyperplasia. The review emphasized the need for differential diagnosis and the careful selection of laboratory markers, such as total testosterone and androstenedione, based on clinical data like puberty history and hirsutism degree. The goal was to determine HA severity, identify androgen synthesis sources, and assess metabolic risks to tailor therapeutic approaches.
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