Definition of Hyperandrogenism

In 2010, the document addressed the difficulties in defining and diagnosing hyperandrogenism and polycystic ovary syndrome (PCOS), pointing out the heterogeneity of symptoms like acne, hirsutism, and androgenic alopecia, and the challenges in measuring biochemical hyperandrogenemia. It reviewed the three formal definitions of PCOS and the subjective nature of conditions like hirsutism, as well as the problems with biochemical measurements, such as the selection of androgens and the timing of measurements. The authors proposed new criteria for assessing hyperandrogenism, including validated scoring systems for clinical features and standardized laboratory procedures for hormone assays. They recommended specific protocols for taking testosterone samples and for reporting anovulation, emphasizing the need for more precise definitions and standardized diagnostic methods to improve the accuracy of hyperandrogenism diagnosis.