Relationship Between Glucose Homeostatic Disorders and Testosterone in Adult Nigerian Women With Polycystic Ovary Syndrome

In a retrospective study involving 224 Nigerian women with polycystic ovary syndrome (PCOS), researchers discovered that 49.1% had glucose homeostatic disorders, with 37.5% exhibiting impaired fasting glucose (IFG) and 11.6% having diabetes mellitus (DM). The study, conducted over a decade, showed a significant correlation between serum total testosterone (TT) levels and fasting plasma glucose (FPG), particularly noting the highest TT levels in the DM group. The findings highlight the commonality of glucose homeostatic disorders in PCOS patients and suggest a link between higher testosterone levels and these disorders. The study underscores the need for glucose disorder screening in PCOS management but notes its limitations, including its retrospective nature, single-center scope, and focus solely on testosterone.