In Vitro Differentiation of Adipose-Derived Stem Cells Into Hair Cell-Like Cells in Guinea Pigs

    December 2007 in “ Journal of Otology ”
    Ying Wang, Dong Min-min, Haibo Yang, Songtao Gao
    TLDR Guinea pig fat stem cells can become hair cell-like cells in a lab.
    The study demonstrated that adipose-derived stem cells (ADSCs) from adult guinea pigs could be differentiated into hair cell-like cells in vitro. By culturing cells from inguinal fat pads with specific factors such as ß-mercaptoethanol, RA, Forskolin, Heregulin, bFGF, BDNF, and EGF, the ADSCs expressed hair cell immunophenotypes, including the hair cell marker protein myosin VIIa. This suggested that ADSCs might be useful as seed cells for tissue engineering applications.
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