A Potential Differentiation of Adipose and Hair Follicle-Derived Mesenchymal Stem Cells to Generate Neurons Induced with EGF, FGF, PDGF, and Forskolin

January 2020 in “ Research Journal of Pharmacy and Technology ”

Fedik Abdul Rantam, Alexander Patera Nugraha, Ferdiansyah Ferdiansyah, Purwati Purwati, Candra Bumi, Helen Susilowati, Eryk Hendrianto, Dwikora Novembri Utomo, Heri Suroto, Christijogo Sumartono, Rosy Setiawati, Cita Rosita Sigit Prakoeswa, Diah Mira Indramaya

adipose derived mesenchymal stem cells hair follicle derived mesenchymal stem cells epidermal growth factor fibroblast growth factor platelet-derived growth factor forskolin hADMSCs hHFDMSCs EGF FGF PDGF

TLDR Fat and hair follicle stem cells can become neurons, useful for treating brain diseases.

The study investigated the neurogenic differentiation potential of Human Adipose Derived Mesenchymal Stem Cells (hADMSCs) and Human Hair Follicle Derived Mesenchymal Stem Cells (hHFDMSCs) when induced with Epidermal Growth Factors (EGF), Fibroblast Growth Factor (FGF), Platelet Derived Growth Factor (PDGF), and Forskolin. Using an in vitro experimental design, the researchers confirmed that both hADMSCs and hHFDMSCs could differentiate into neurons, as evidenced by the expression of neural markers such as glial fibrillary acidic protein, nestin, and β-tubulin III. The findings suggested that these stem cells have similar capacities for neuronal differentiation, which could be advantageous for developing therapies for neurological diseases.

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