Neurotrophic Effects of Silibinin on Differentiation of Hair Follicle Stem Cells to Neurons

    May 2012 in “ DOAJ (DOAJ: Directory of Open Access Journals) ”
    Sara Asalgoo
    TLDR Silibinin helps hair follicle stem cells become neurons at 0.5 μg/ml, but higher doses are toxic.
    The study investigated the neurotrophic effects of silibinin on the differentiation of hair follicle stem cells into neurons. It was found that silibinin at a concentration of 0.5 μg/ml significantly promoted the differentiation of these stem cells into neurons, as indicated by the expression of the β III tubulin marker. However, concentrations of 1 μg/ml or higher were toxic and inhibited cell growth, while concentrations below 0.1 μg/ml had no effect on proliferation or differentiation. The combination of silibinin with neurotrophin-3 further enhanced stem cell differentiation.
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