In Vitro Differentiation of Hair-Follicle Bulge Stem Cells Into Synaptophysin-Expressing Neurons: A Potential New Approach for Neuro-Regeneration

    November 2024 in “ Human Cell ”
    Mohamad Mahjoor, Maliheh Nobakht, Fatemehsadat Ataei Kachouei … Nayereh Sajedi
    Studysummary This study found that treating rat whisker follicle stem cells with retinoic acid and epidermal growth factor induced them to express synaptophysin, a marker of mature neurons, although there was a reduction in other neural markers, suggesting potential for neuro-regeneration applications.
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    Research cited in this study 7

    1. A Potential Differentiation of Adipose and Hair Follicle-Derived Mesenchymal Stem Cells to Generate Neurons Induced with EGF, FGF, PDGF, and Forskolin Research Journal of Pharmacy and Technology · 2020
    2. Hair Follicle Stem Cells: In Vitro and In Vivo Neural Differentiation World journal of stem cells · 2015
    3. In Vitro Neural Differentiation of CD34+ Stem Cell Populations in Hair Follicles by Three Different Neural Induction Protocols In vitro cellular & developmental biology. Animal · 2014
    4. Evaluation of the Effect of NT-3 and Biodegradable Poly-L-Lactic Acid Nanofiber Scaffolds on Differentiation of Rat Hair Follicle Stem Cells into Neural Cells In Vitro Journal of Molecular Neuroscience · 2013
    5. Nestin-Positive Hair Follicle Pluripotent Stem Cells Can Promote Regeneration of Impinged Peripheral Nerve Injury The Journal of Dermatology · 2011
    6. Bulge Cells of Rat Hair Follicles: Isolation, Cultivation, Morphological and Biological Features 2010
    7. Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons Proceedings of the National Academy of Sciences · 2005

    Related research 1

    1. Regeneration of Hair Follicles Is Modulated by Flightless I (Flii) in a Rodent Vibrissa Model Journal of Investigative Dermatology · 2010