Cross-Interactions of BMP and WNT Signaling Pathways Attenuate Androgen Effect on Hair Follicle Stem Cell Differentiation

September 2019 in “ Journal of Investigative Dermatology ”

Julieta María Ceruti, Florencia Maia Oppenheimer, Gustavo José Leirós, María Eugenia Balañá

BMP Bone Morphogenetic Proteins hair follicle stem cell HFSC androgens androgenetic alopecia AGA alkaline phosphatase dermal papilla cells DPC DHT BMP2 ß-catenin WNT signaling pathway epithelial-mesenchymal interaction

Studysummary This study found that BMPs can counteract the inhibitory effects of androgens on hair follicle stem cell differentiation, highlighting their critical role in the pathway dysregulation seen in androgenetic alopecia.

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