HSP90 Inhibition and Cellular Stress Elicits Phenotypic Plasticity in Hematopoietic Differentiation

    October 2017 in “ Cellular Reprogramming ”
    Abdalla A. Lawag, Jennifer M. Napper, Caroline A. Hunter, Nickolas A. Bacon, Seth Deskins, Manaf El-hamdani, Sarah-Leigh Govender, Emine C. Koc, Vincent E. Sollars
    TLDR Inhibiting HSP90 increases cell adaptability and survival under stress.
    The study investigated the role of HSP90 inhibition in promoting cellular plasticity in a murine model of hematopoietic differentiation. It was found that inhibiting HSP90, using geldanamycin, increased cellular plasticity, allowing cells to better adapt and survive under stress conditions. This plasticity was linked to epigenetic mechanisms and required high levels of stem cell factor signaling. The findings suggested that HSP90 and cellular stress played a significant role in inducing phenotypic plasticity, which could have implications for understanding cancer progression and evolution.
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