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This study found that a commonly-used DHT enzyme immunoassay shows significant cross-reactivity with testosterone, leading to inaccurate DHT measurements compared to a gold-standard LC–MS/MS method.

This study found that sulforaphane treatment enhanced hair regeneration in ob/ob mice by increasing DHT-degrading enzyme levels and lowering plasma testosterone and DHT.

This study found that hair follicle cells' growth in vitro is influenced by the concentration of androgens and antiandrogens, with papilla cells and outer root sheath keratinocytes showing distinct sensitivity.

This study developed a reliable and convenient cell-based model to screen for type II 5α-reductase inhibitors, identifying Curcumae longae and Mori ramulus extracts as potential candidates.

This review of studies on prostate cancer chemoprevention in Europe reports no robust evidence supporting the effectiveness of chemopreventive agents, though vitamin E and selenium may potentially contribute to prevention efforts.

This review discusses various targets for treating prostate cancer and benign prostatic hyperplasia and reports on recent studies of new compounds and 5α-reductase inhibitors, but provides no new experimental results.

This study found that dihydrotestosterone (DHT) suppresses prostaglandin E2 and TGF-β induced IGF-I gene promoter activity in osteoblasts, suggesting complex interactions among bone growth regulators and potential complications from anabolic steroid use.

In this animal study, petroleum ether and ethanolic extracts of Abrus precatorius seeds appeared to reverse androgen-induced alopecia in male albino rats by inhibiting the 5α-reductase enzyme, similar to finasteride.

This study found that girls with prepubertal simple hypertrichosis had significantly higher plasma levels of dihydrotestosterone compared to controls, which does not align with other androgen markers and warrants further investigation.

This study found that LY320236 is a competitive inhibitor of type I and a non-competitive inhibitor of type II steroid 5alpha-reductase, indicating its potential as a dual inhibitor with differing modes of activity.

This study reported that 5 alpha-reductase type 2 is the predominant enzyme in pubic skin fibroblasts across normal men, women, and hirsute patients, suggesting potential treatment options for idiopathic hirsutism.

This study found that resveratrol significantly alleviated testicular damage in male rats caused by finasteride, which otherwise led to decreased testosterone levels and various histopathological alterations in the testes.

In this case study, researchers observed that steroidogenesis from adrenal androgens in prostate cancer tissues may explain progression in a 74-year-old man with low circulating testosterone.

This study identified ten novel compounds that may effectively target steroid 5 alpha-reductase 2 (5αR-2) for potential treatment of benign prostate hyperplasia, exhibiting comparable binding energies to existing drugs like finasteride and dutasteride.

This study found that developmental changes in testosterone synthesis and gene regulation may explain age differences in corticosterone release in response to stress between adolescent and adult rats.

This review highlights men's cosmetic interests, focusing on maintaining a masculine appearance while managing scalp hair, facial lines, and other aging signs, but presents no new findings.

This review discusses trends in testosterone therapy use for male hypogonadism and reports no new clinical results, noting a shift towards more convenient and physiological treatments.

In this study, oral finasteride therapy was associated with decreased DHT levels and improved hair loss severity in young male AGA patients, while hormonal changes influenced the curative effect.

This abstract suggests that finasteride's suppression of DHT may link DHT to migraine causes, or it may benefit migraines by other finasteride properties like testosterone modulation, but reports no new empirical findings.

This study found that the in vitro growth of hair follicle cells, particularly papilla cells and outer root sheath keratinocytes, is influenced by different concentrations of androgens and antiandrogens.

This study observed that integrating best practices for anabolic androgenic steroid users into Swiss primary care is feasible and well-accepted, though current doping laws hinder adequate medical care for this population.

This review discusses the potential of plant-derived phytochemicals as alternatives to 5-alpha-Reductase inhibitors in treating prostate cancer, highlighting possible benefits like reduced side effects, but it reports no new findings.

This study investigated the effects of the 60% alcohol extract from Alnus sibirica and its active compound, oregonin, on hair health, observing anti-oxidative and anti-apoptotic benefits in human hair dermal papilla cells exposed to oxidative stress, suggesting potential as natural materials for hair loss prevention.

This study observed that a topical liposome formulation of a 5‐α‐reductase inhibitor effectively reduced the size of treated sebaceous glands and induced apoptosis in a hamster model, suggesting potential benefits for acne treatment.

This study found that the androgen precursors DHEA and androstenedione stimulated androgen-sensitive parameters in the sebaceous glands of the skin in castrated male hamsters.

This study found that the 5α-steroid metabolite profile in men with inherited 5α-reductase deficiency is similar to those taking the drug finasteride, suggesting the gene affects multiple steroid substrates.

This preclinical study observed that a nanoencapsulated ingredient complex, AcPi, may prevent hair follicle aging and hair loss by reducing oxidative stress, enhancing mitochondrial activity and WNT/β-catenin signaling, and controlling androgenic metabolism when tested on human scalp cultures.

Targeting androgen receptors with antiandrogen oligonucleotides could effectively treat hair loss.

This study suggests that guava leaf extract may inhibit hair loss by downregulating genes involved in androgen synthesis, potentially offering a natural alternative for treating androgenetic alopecia.

This study found that black cohosh extract BNO 1055 reduced testosterone-induced prostate and seminal vesicle growth in rats, suggesting it may contain potent 5α-reductase inhibitors useful for prostate cancer prevention.