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This study found that dermal papilla cells from different scalp regions of AGA patients showed differential gene expression related to cell proliferation, apoptosis, and signaling pathways when exposed to DHT in a 3D culture.

In this study, researchers observed that Indian head cactus extract significantly increased the proliferation of human follicle dermal papilla cells and induced the expression of hair growth-related genes, suggesting its potential as a new therapy for promoting hair growth.

This study found that in laboratory settings, dermal papilla cells cultured as spheroids showed significantly higher hair inductive potential and angiogenic factor expression compared to monolayer cultures.

This study identifies a specific cell population, PDGFRα+/Sca1+/CD34+ mesenchymal cells, which play a crucial role in regenerating hair follicles by promoting the downgrowth phase of the hair cycle, offering insights into organ morphogenesis and stem cell niches essential for adult hair regeneration.

This review discusses advances in using tissue engineering to improve the inductivity of dermal papilla cells for hair follicle restoration and reports no new clinical results.

In this study, researchers found that the interaction between dermal papilla and endothelial cells decreases with age, affecting signaling pathways that promote hair regeneration and angiogenesis in mouse models.

This study found that cultured papilla cells can induce follicle formation and hair growth when combined with different epidermal and dermal cells, highlighting their powerful inductive properties and potential for dermatological applications.

This study found that altering cell culture conditions to form three-dimensional papilla spheroids can restore the ability of human dermal papilla cells to induce hair growth in adult skin.

This study found that combining adult germinative epidermal cells with non-inductive dermal cells can stimulate hair follicle neogenesis, effectively altering the cells' status to enhance induction.

This study found that dermal fibroblast cultures, especially those with higher alpha-smooth muscle actin expression, can be used to produce skin-derived precursor cells, unlike human hair follicle dermal papilla cultures.

This review discusses the biology and signaling mechanisms of dermal papilla cells in hair follicle growth and reports no new clinical results; the authors emphasize the importance of optimizing culture conditions for hair restoration.

This study demonstrated that a 3D air–liquid culture system using Wnt-CM-treated cells can induce hair regeneration in nude mice and may facilitate large-scale preparation for hair loss treatment.

This study found that direct interactions between human dermal papilla cells and melanocytes under low oxygen conditions improved cell functions and could be important for hair regeneration efforts.

This study identified distinct and diverse fibroblast populations in female scalp cells that lose their signature and identity with age, highlighting significant age-related changes, such as increased fibrosis, DNA damage, and senescence, which may affect scalp dermal support for healthy hair follicles.

This study suggests that inaudible sound at 30 kHz may promote hair growth and inhibit hair loss signals in human dermal papilla cells, indicating potential as a new treatment for androgenic alopecia.

This study demonstrated that injecting reconstructed dermal papilla-like tissues in mice led to new hair growth, suggesting potential future applications in hair transplantation and baldness treatment.

This study found that the culture conditions, not species-specific differences, determined whether sika deer dermal papilla cells adopted a 3D spheroidal or 2D monolayer growth pattern, influencing their hair-inducing ability.

This study found that TGF-β2 may enhance collagen expression and spheroid formation in human dermal papilla cells, which could improve their hair inductivity and maintenance.

This study isolated a bioactive peptide from Trapa japonica fruit and found that it may protect human dermal papilla cells from DHT-induced stress, suggesting potential for biomedical applications.

This study found that calcium microcapsules exhibited better biocompatibility and cell viability than barium microcapsules for scaffolding in artificial dermal papilla, suggesting potential for developing new hair follicle structures.

This study found that a 3D Matrigel culture technique for dermal papilla cell spheroids can enhance hair follicle inductivity and induce hair-like fiber differentiation in vitro, even with high-passage cells.

This study found CK19/Bcl-2-positive and Bax-negative cells in hair follicle cultures from plucked hairs, supporting their potential identification as follicular stem cells located in the bulge area.

This study found that colchicine treatment significantly reduced hair fiber elongation in cultured hair follicles and altered protein expression and activity in dermal papilla cells, suggesting a role for the ubiquitin-proteasome system in its effects.

This study suggests that mesenchymal stem cell therapy may improve cell viability and regulate key signaling pathways in vitro for treating alopecia areata.

This study suggests that red deer stags provide a novel model for investigating hormonal regulation of hair growth due to the different cell growth rates in hair follicles during breeding and nonbreeding seasons.

This study observed that cultured dermal papilla cells showed distinct functional properties from dermal fibroblasts, including lower proliferation rates, higher adhesion to collagen type IV, and different cell-matrix interactions.

This study suggests that interleukin-1 α influences dermal papilla cell activity by modifying androgen receptor expression and increasing the secretion of several growth factors and cytokines.

This study developed a method for expanding human dermal papilla cells in vitro while maintaining their ability to induce hair growth, advancing the potential for follicular cell implantation as a treatment for hair loss.

This study found that dermal papilla cells from human hair follicles form multi-layered aggregates when cultured in vitro, contrasting with the monolayer growth of dermal fibroblasts.

This study suggests that exosomes derived from dermal papilla cells, especially those cultured in three dimensions, promote hair growth and regeneration by enhancing follicular cell activity.