Fully Functional Hair Follicle Organ Regeneration Using Organ-Inductive Potential Stem Cells With an Accessory Mesenchymal Cell Population in an In Vitro Culture System

    Koh-ei Toyoshima, Ayako Tsuchiya, Miho Ogawa, Miki Takase, Tarou Irié, M. Yanagisawa, Richard H. Kaszynski, Hiroshi Fujimaki, Kyoko Baba, Takayuki Sugimoto, Akira Takeda, Akira Sato, Takashi Tsuji
    TLDR Scientists successfully regenerated functional hair follicles using specific stem cells and mesenchymal cells.
    The study demonstrates the successful in vitro regeneration of fully functional hair follicles using bioengineered hair follicle germs composed of epithelial stem cells, dermal papilla (DP) cells, and an accessory mesenchymal cell population. These cells, identified as PDGFRα+/Sca1+/CD34high+ mesenchymal cells, play a critical role in hair follicle downgrowth and development by interacting with bulge-derived epithelial stem cells and DP cells. The bioengineered follicles were capable of undergoing natural hair cycles and producing functional hair upon transplantation into mice. This research highlights the potential for using bioengineered hair follicles in regenerative medicine and hair transplantation, offering insights into stem/progenitor cell interactions and autonomous regenerative responses.
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