Single-Cell RNA Sequencing of Different Fibroblast Populations Cultured from Female Scalp Reveals Significant Alterations to Transcriptional Profiles with Age

April 2023 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

R. Baker, R. Williams, G. Westgate, A. Pawlus, J. Zguris, J. Thornton

single-cell RNA sequencing dermal fibroblasts dermal sheath dermal papilla fibrosis-related gene sets contractile markers DNA damage senescence hair follicles scRNA-seq DF DS DP

TLDR Aging changes female scalp cells, likely affecting hair health.

This study utilized single-cell RNA sequencing to analyze age-related transcriptional changes in dermal fibroblasts (DF), dermal sheath (DS), and dermal papilla (DP) cells from the scalps of 18 female donors aged 20-77 years. A total of 51,774 cells were sequenced, revealing 19 distinct transcriptional clusters. The findings indicated significant age-related alterations, with older donors showing increased fibrosis-related gene sets in DFs, loss of contractile markers in DS cells, and elevated DNA damage and senescence in DP cells. These changes suggest that aging affects the scalp's ability to support healthy hair follicles, contributing to age-related scalp and hair changes in females.

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207 citations, March 2012 in “Development”

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