207 citations
,
September 2002 in “The Journal of clinical investigation/The journal of clinical investigation” The study found that reducing testosterone in male mice through castration or androgen antagonism significantly accelerated wound healing by decreasing inflammation, suggesting a potential therapeutic target for impaired healing in elderly men.
180 citations
,
January 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that vitamin D receptor knockout mice exhibit impaired epidermal differentiation and progressive hair loss, suggesting the importance of the vitamin D receptor in normal skin and hair follicle development.
105 citations
,
December 1998 in “Archives of Dermatological Research” This study found that dermal papilla cells in human hair follicles exhibit stronger expression of VEGF mRNA and protein compared to other follicular cells, suggesting their key role in angiogenic processes related to hair growth.
90 citations
,
January 1979 in “International review of cytology” This chapter reviews the complexity of hair and wool follicle formation, emphasizing the importance of cytological studies to understand the relationship between cellular components.
88 citations
,
May 2005 in “Journal of Dermatological Science” In this study, specific versican expression was observed in the anagen phase of human hair follicles, suggesting its importance in maintaining normal hair growth.
66 citations
,
January 2000 in “Hormone Research in Paediatrics” This study suggests that the paradoxical effects of androgens on hair growth are due to differential gene expression in hair follicles, possibly established during embryogenesis.
56 citations
,
August 2005 in “Journal of Investigative Dermatology Symposium Proceedings” This review discusses the complex interaction between androgens and hair follicle biology, highlighting the need for a better understanding to improve hirsutism treatments, but reports no new results.
51 citations
,
April 2020 in “Cells” This study found that macrophage extracellular vesicles enriched with Wnt proteins significantly promoted hair follicle growth in mice and increased hair shaft size in human hair follicles, suggesting potential clinical use for treating hair loss.
45 citations
,
July 2009 in “Journal of Investigative Dermatology” This study reported significant upregulation and release of S100A4 in psoriatic skin, which may actively contribute to psoriasis pathogenesis.
41 citations
,
July 1994 in “Journal of Dermatological Science” This review examines the differentiation potential of epithelial cells from various sources in hair follicle formation, concluding that complex interactions are required for hair-specific characteristics, which were achieved in vivo but not in vitro.
39 citations
,
April 1992 in “Development” In this study, researchers detailed how hair follicles regenerate after microsurgical amputation, observing a wound reaction involving dynamic dermal-epidermal interactions and changes in extracellular matrix components.
36 citations
,
July 2022 in “Stem Cell Research & Therapy” This study concluded that using adipose tissue-derived stromal vascular fraction significantly improved acne scars by increasing collagen content and skin thickness compared to nanofat alone.
34 citations
,
July 2018 in “Veterinary Dermatology” This study established a 3D in vitro culture system of canine keratinocyte organoids to study epidermal function and address skin disorders in dogs, though additional growth factors are needed for hair follicle development.
33 citations
,
September 2019 in “Dermatologic Surgery” This study found that intradermal administration of adipose-derived stem cell–conditioned medium significantly increased hair density and dermal thickness, suggesting potential regenerative effects on both hair follicles and the interfollicular scalp in patients with alopecia.
33 citations
,
January 2006 in “Journal of Dermatological Science” This article reviews the molecular interactions involved in hair follicle cycling and highlights the role of dermal papilla cells, but it presents no new research findings.
31 citations
,
February 2014 in “Journal of dermatological science” This study found that placental growth factor (PlGF) enhanced hair shaft elongation and accelerated hair follicle growth, suggesting its potential as a therapeutic target for alopecia.
30 citations
,
December 2014 in “Toxicological Research” This study found that 3% peppermint oil significantly enhanced hair growth in C57BL/6 mice, showing increased dermal thickness, follicle number, and follicle depth compared to other treatments.
29 citations
,
March 2014 in “PloS one” In this study, Astragaloside IV was found to inhibit apoptosis-related pathways in hair follicles of mice, suggesting it may serve as an alternative therapy for hair loss.
23 citations
,
January 2021 in “Scientific Reports” In this study, hair follicle germs containing vascular endothelial cells showed improved hair regeneration and morphogenesis-related gene expression in mice, suggesting a promising strategy for hair regenerative medicine.
23 citations
,
October 1996 in “Dermatologic clinics” This review discusses genomic and postgenomic alterations in chronic degenerative diseases and potential modulation by dietary and pharmacological agents, reporting no new clinical results.
21 citations
,
April 2019 in “Endocrinology and Metabolism Clinics of North America” This review discusses skin diseases in transgender patients receiving gender-affirming hormone therapy and procedures, highlighting unique conditions and the underdiagnosis that affects their quality of life and mental health.
20 citations
,
August 2007 in “Molecular therapy” This study found that inducing hair follicles into the anagen-onset stage in mice enhances the immune response to a topically applied DNA vaccine against anthrax.
17 citations
,
August 2012 in “Archives of Pharmacal Research” Acankoreoside J from Acanthopanax koreanum may help promote hair growth.
17 citations
,
December 2004 in “The Journal of Men's Health & Gender” This article discusses the role of androgens in hair follicle changes, explaining how dihydrotestosterone contributes to hair thinning on the scalp, while promoting thicker facial hair in men, and reports no new clinical results.
16 citations
,
October 1996 in “PubMed” This study concluded that hormonal replacement therapy can improve skin ageing symptoms by increasing skin thickness and alleviating dryness and hyposeborrhoea in postmenopausal women.
14 citations
,
March 2017 in “Plastic and reconstructive surgery. Global open” In this study, various types of minor hair follicle damage were observed during follicular unit extraction, with paring and hair bulb injury being more apparent under microscopic examination.
13 citations
,
June 2020 in “International Journal of Molecular Sciences” This study found that the humanin analogue HNG significantly promoted hair growth in vitro and in vivo by prolonging the anagen phase and inhibiting hair follicle cell apoptosis in mice.
11 citations
,
October 2016 in “Biomedicine & Pharmacotherapy” In this study, minoxidil and human platelet lysate affected gene expression related to hair growth signaling pathways in mouse hair follicle cells.
10 citations
,
February 2014 in “Fitoterapia” This study found that Pomiferin may effectively stimulate extracellular matrix protein expression in skin and scalp models, with results comparable to retinol, suggesting potential as a topical treatment ingredient.
10 citations
,
January 2003 in “Journal der Deutschen Dermatologischen Gesellschaft” In this study, hydroxychloroquine treatment in patients with scleromyxoedema led to complete or partial remission of skin symptoms and improved mobility, though it did not affect paraproteinaemia.