research A Subpopulation of Itch-Sensing Neurons Marked by Ret and Somatostatin Expression
Scientists found a specific group of itch-sensing nerve cells in mice important for feeling itch but not for sensing heat or touch.
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research Stem Cell Plasticity Enables Hair Regeneration Following Lgr5+ Cell Loss
Hair can regrow after certain stem cells are lost because other stem cells can take over their role.
research Hair Corticosterone Measurement in Mouse Models of Type 1 and Type 2 Diabetes Mellitus
New hair growth corticosterone levels are higher in diabetic mice, indicating long-term stress.
research Hedgehog Signaling Reprograms Hair Follicle Niche Fibroblasts to a Hyper-Activated State
Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.
research Immunoreactivity of the SARS-CoV-2 Entry Proteins ACE-2 and TMPRSS-2 in Murine Models of Hormonal Manipulation, Aging, and Cardiac Injury
Age affects how certain proteins involved in COVID-19 infection are expressed in mice, but sex hormones and heart injury do not.
research The Transcriptional Regulator Prdm1 Is Essential for the Early Development of the Sensory Whisker Follicle and Is Linked to the Beta-Catenin First Dermal Signal
Prdm1 is necessary for early whisker development in mice but not for other hair, and its absence changes nerve and brain patterns related to whiskers.
research Epidermal Retinol Dehydrogenases Cyclically Regulate Stem Cell Markers and Clock Genes and Influence Hair Composition
Enzymes involved in Vitamin A metabolism affect hair growth and type in mice.
research Distinct Stem Cells Contribute to Mammary Gland Development and Maintenance
Different types of long-lasting stem cells are responsible for the growth and upkeep of the mammary gland.
research Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata
MDSC-Exo can treat autoimmune alopecia areata and promote hair regrowth in mice.
research The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but Not for Maintenance of the Epidermal Stem Cell Compartment
Vitamin D Receptor is needed for hair growth in mice but not for skin stem cell maintenance.
research Novel Aspects of Age-Protection by Spermidine Supplementation Are Associated with Preserved Telomere Length
Spermidine helps protect against aging by preserving telomere length.
research Novel Insights Into the Pathways Regulating the Canine Hair Cycle and Their Deregulation in Alopecia X
The study concluded that similar pathways regulate hair growth in dogs and mice, and these pathways are disrupted in dogs with Alopecia X, affecting stem cells and hormone metabolism.
research Improvement of Androgenic Alopecia by Extracellular Vesicles Secreted from Hyaluronic Acid-Stimulated Induced Mesenchymal Stem Cells
HA-stimulated stem cell vesicles improved hair growth in male mice with androgenetic alopecia.
research Murine Sebaceous Gland Homeostasis Requires Intact Cutaneous Innervation in a Hair Cycle-Dependent Context
Mouse skin glands need healthy nerves to grow properly during hair growth phases.
research Control of Hair Follicle Cell Fate by Underlying Mesenchyme Through a CSL–Wnt5a–FoxN1 Regulatory Axis
Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.
research Learning From Nudity: Lessons From The Nude Phenotype
The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.
research Proliferative and Non-Proliferative Lesions of the Rat and Mouse Integument
The project created a standardized system for classifying skin lesions in lab rats and mice.
research Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation and Attenuates Adverse Cardiac Remodeling in the Infarcted Diabetic Heart
Fibroblast Growth Factor-9 (FGF-9) can help improve heart function in diabetic mice after a heart attack by reducing inflammation and harmful changes to the heart's structure.
research The HPV16 Oncogenes Cause Aberrant Stem Cell Mobilization
HPV16 oncogenes disrupt the normal activity of hair follicle stem cells.
research Targeting Evasion of Immune Pathways in Glioblastoma
Some brain cancer cells avoid immune system detection, and certain treatments could target this to slow their growth; also, certain fat cell precursors help regenerate hair and skin after injury.
research How the Stress of Fight or Flight Turns Hair White
Stress turns hair white by depleting color-giving cells in hair follicles through a specific neurotransmitter related to the body's stress response.
research CD80CD86 Deficiency Disrupts Regulatory CD4+FoxP3+ T Cell Homeostasis and Induces Autoimmune-Like Alopecia
CD80CD86 deficiency causes hair loss by disrupting regulatory T cells.
research Subchronic Study of Sperm Morphology, Genotoxic and Mutagenic Effect of Lepidium Sativum Seeds Aqueous Extract In Vivo
High doses of Lepidium sativum seed extract are toxic and should be used with caution.
research Decision Letter: Hair Follicle Epidermal Stem Cells Define a Niche for Tactile Sensation
Hair follicle stem cells are crucial for touch sensation and proper nerve structure in mice.
research Flexible Fate Determination Ensures Robust Differentiation in the Skin Hair Follicle
Hair follicle stem cells can change their role to ensure proper hair development.
research The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling
Cathepsin L is essential for normal hair growth and development.
research Food Deprivation-Induced Expression of Minoxidil Sulfotransferase in the Hypothalamus Uncovered by Microarray Analysis
Food deprivation increases MST enzyme in the brain, possibly affecting energy balance.
research Inactivation of Autophagy Leads to Changes in Sebaceous Gland Morphology and Function
Autophagy is crucial for normal sebaceous gland function and sebum composition.
research Suppression of Wnt/β-Catenin Signaling by EGF Receptor Is Required for Hair Follicle Development
Blocking Wnt/β-catenin signaling with EGF receptor is necessary for proper hair growth.
research The Hair Follicle Bulge: A Niche for Adult Stem Cells
The hair follicle bulge is an important area for adult stem cells involved in hair growth and repair, with potential for medical use needing more research.