Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that combining ultrasound with a GelMA hydrogel able to deliver mesenchymal stem cell-derived vesicles significantly improved wound healing in a mouse model by enhancing fibroblast activity, promoting re-epithelialization, and facilitating hair follicle regeneration, highlighting a novel approach to skin regeneration therapy.

This study reviewed recent advances in regenerative technologies for aesthetic and reconstructive medicine and found that adipose-derived stem cells and platelet-rich plasma are well-established for tissue repair due to their safety and effectiveness, while emerging technologies like exosome-based therapies hold future potential.

In this study using a mouse model, ECM/SVF-CM, derived from adipose-derived stem cells, was observed to stimulate hair growth more effectively than SVF-CM by promoting cell proliferation, neovascularization, and anagen induction, which may support its potential as an improved treatment for hair loss.

This study found that the DexIEME hydrogel promotes complete skin regeneration and scar attenuation in murine and porcine models, suggesting potential for treating deep dermal injuries.

This study found that combining a human acellular amniotic membrane with iPSC-derived epithelial stem cells effectively repaired skin defects and promoted hair follicle formation in nude mice.

This study found that conditioned media from epidermal progenitor cells improved skin aging signs in a clinical trial and protected fibroblasts from oxidative stress in vitro.

This study developed in vitro methods to regenerate hair follicles and erector muscles by mimicking their native structures and mechanical conditions, reconstructing hair follicle-like structures and forming muscle-like tissues.

This review discusses the advances and challenges of using mesenchymal stem cell-derived extracellular vesicles in therapeutic applications and reports no new clinical findings.

This study suggests that a novel micropatterned dermal–epidermal matrix (μDERM) enhances keratinocyte function and epidermal morphology, offering potential improvements in skin substitute design for wound healing applications.

This study found that gelatin sponges used as scaffolds in rats with deep wounds and periosteal defects enabled regeneration of diverse tissue types, including periosteum, skin, and appendages, highlighting the role of vascular niche formation.

This study by Bansaccal et al. found that skin with higher levels of type I collagen density and elasticity in the dermis can inhibit basal cell carcinoma development and spread by acting as a natural barrier against cell reprogramming in mice.

This study found that incorporating cell-adhesive ligands into 3D peptide hydrogels supports the survival and osteogenic differentiation of human amniotic mesenchymal stem cells.

This study achieved regeneration of hair follicle-like structures and erector muscle of hair in vitro by simulating cellular organization and applying mechanical stimuli.

This review examines current and potential approaches to managing chronic wound inflammation through macrophage-targeted strategies using ECM-inspired wound dressings, but it reports no new clinical results.

This study developed microfluidic-assisted GelMA-MSC/HAD-EPC microspheres that efficiently generated hair follicles in nude mice, suggesting a promising strategy for advancing hair-regenerative medicine.

This study developed a biomimetic 3-D co-culture system that enhances the hair-inductive properties of human dermal papilla cell aggregates, potentially improving hair follicle tissue engineering.

In a study using a rat model, researchers developed injectable hydrogels from antler reserve mesenchyme which enhanced regenerative healing of full-thickness cutaneous wounds by creating a fetal-like niche that increased stem cell presence and modulated gene expression related to wound healing.

This research presents a comprehensive workflow for producing EMA-compliant autologous keratinocyte-based therapies for wound healing and explores miRNA-mediated regulations in human keratinocytes and adipose-derived mesenchymal stem cells.

This study demonstrates that transfected epidermal stem cells using a novel 3D transfection system significantly enhanced wound healing and may serve as an effective therapeutic agent and gene delivery method for wound treatment.

This review summarizes the therapeutic potential and development of engineered extracellular vesicles for tissue repair and regenerative medicine, reporting no new clinical findings.

This review suggests that omitting the proteolysis step and including tissue pieces in mesenchymal stem cell isolation may improve cell quality, reduce contamination risk, and lower costs and processing time in clinical applications.

The researchers reported that conditioned media from deer antler mesenchymal stem cells may enhance hair and skin regeneration by modulating cellular responses through secretory vesicles.

This study found that an acellular dermal matrix derived from tilapia skin significantly accelerated wound healing and improved tissue regeneration quality in mouse and pig models compared to a commercial porcine-derived matrix, suggesting its potential as a safe, cost-effective bioscaffold for skin repair.

This research reported that dermal progenitor cells can enhance split-thickness skin graft outcomes by improving dermal layer qualities and reducing itch and offer potential in skin wound healing using a flowable hydrogel for better cell delivery and survival.

This review discusses autologous tissue engineering strategies and skin-derived stem cell transplantation products, noting clinical challenges and highlighting ongoing trial activities, without reporting new clinical outcomes.

This study demonstrated that a bio-3D printed artificial skin scaffold, seeded with adipose-derived mesenchymal stem cells, showed promising wound healing properties by enhancing cell recruitment, migration, and gene expression related to tissue regeneration.

This study found that incorporating dermal papillae cells and keratinocytes into dermal substitutes promoted better wound healing, reduced contraction, and enabled appendage formation in tissue-engineered skin on mice.

This study found that injecting xeno-free, three-dimensional cell masses from human adipose-derived stem cells improved blood perfusion and preserved limb function in mice without causing tumors or toxicity, suggesting potential for treating severe ischemic diseases.