Fish Acellular Dermal Matrix Promotes Repair of Full-Thickness Skin Defects in Mice and Bama Pigs

The study evaluates the effectiveness of Fish Acellular Dermal Matrix (FADM) derived from tilapia in enhancing the repair of full-thickness skin defects in Balb/c mice and Bama pigs. FADM demonstrated superior biocompatibility, minimal cytotoxicity, and non-haemolytic properties compared to porcine acellular dermal matrices (PADMs), making it a safer alternative for wound healing. It significantly improved cell proliferation, migration, angiogenesis, and collagen deposition, achieving a 92% healing rate in mice and a 71% rate in Bama pigs. The matrix retained bioactive factors like FGF and TGF-β, crucial for tissue repair, and activated signaling pathways such as PI3K/AKT, which are important for inflammation regulation and extracellular matrix remodeling. The study concludes that FADM is a promising and economically feasible biomaterial for clinical applications in wound repair.