27 citations
,
January 2018 in “Drug Delivery” In this study, researchers investigated a new local drug delivery system using glycol chitosan hydrogel and doxorubicin (GC10/DOX) for thyroid cancer in mice, finding it produced a stronger antitumor effect compared to conventional treatment methods.
22 citations
,
August 2020 in “Molecules” This study found that applying AGN root extract containing decursin to mouse skin accelerated hair growth and altered inflammatory cytokine levels compared to a control.
22 citations
,
December 2017 in “International Journal of Molecular Sciences” This study found that millimolar concentrations of minoxidil in the skin induced VEGF production through HIF-1 stabilization by inhibiting PHD-2, implying a molecular mechanism for hair growth promotion.
22 citations
,
March 2017 in “Scientific reports” This study investigated the role of NLRP3 inflammasomes in alopecia areata and found that outer root sheath cells may contribute to inflammation by increasing IL-1β and HMGB1 secretion when stimulated with double-stranded RNA.
20 citations
,
December 2013 in “PTR. Phytotherapy research/Phytotherapy research” This study found that ginsenoside Rg3 up-regulates vascular endothelial growth factor expression in human dermal papilla cells and mouse hair follicles, suggesting its potential role in promoting hair growth.
20 citations
,
February 2022 in “Pharmaceutics” This study found that idebenone-loaded nanoparticles (IB@NPs) improved stability, antioxidant activity, and wound healing capacity in vitro, suggesting potential applications in cosmetic and pharmaceutical fields.
16 citations
,
March 2014 in “Journal of the European Academy of Dermatology and Venereology” This study found that acne was the most common dermatological manifestation in Korean women with polycystic ovary syndrome, particularly those with a specific combination of symptoms, showing distinct variations in serum hormonal and metabolic parameters.
16 citations
,
November 2003 in “Journal of the American Academy of Dermatology” Iron therapy cured the boy's hair color issue.
15 citations
,
June 2023 in “Journal of Microbiology and Biotechnology” In this study, researchers found that an ethyl acetate extract of the green microalga Scenedesmus deserticola significantly increased the viability of human dermal fibroblasts by over 20% compared to a control and identified a potent anti-UV compound, loliolide, through further fractionation.
15 citations
,
January 2018 in “Annals of Dermatology” Wigs significantly improve the well-being of people with severe hair loss.
14 citations
,
December 2013 in “Experimental Dermatology” The T-zone on the face has more androgen receptors and produces more oil than the U-zone.
11 citations
,
April 2016 in “Dermatologic Surgery” This study concluded that to accurately calculate the transection rate in follicular unit extraction, it's essential to account for both extracted and hidden transections, which differ based on surgeon expertise.
11 citations
,
March 2015 in “Life sciences” This study found that using conditioned medium from vitamin D3 pre-activated preadipocytes enhanced hair regeneration in mice by promoting angiogenesis.
11 citations
,
April 2013 in “Journal of Proteomics” This study identified proteins that are differentially expressed in balding versus non-balding dermal papilla cells, potentially aiding the understanding and treatment of androgenetic alopecia.
10 citations
,
January 2015 in “European journal of pharmacology” In this animal study, ginsenoside Rb1 demonstrated therapeutic effects on hypertrophic scar remodeling, with the highest efficacy observed at a dose of 0.56 mg.
10 citations
,
January 2008 in “Acta dermato-venereologica” This report describes a case of diffuse hair loss and palmoplantar psoriasiform eruptions in a 52-year-old woman, potentially linked to her use of carbamazepine, with improvement after reducing the drug's dosage.
9 citations
,
November 2016 in “Archives of Plastic Surgery” In this study, researchers found that a mixture of Saccharina japonica and Undaria pinnatifida (L-U mixture) promoted hair growth in mice comparably to 3% minoxidil. The L-U mixture stimulated hair growth-promoting genes and suppressed hair loss-related genes, suggesting its potential for hair loss treatments.
9 citations
,
October 2013 in “Journal of Investigative Dermatology” This study found that the OVOL1 gene in mouse neonatal dermal cells is crucial for hair follicle neogenesis, suggesting it plays a significant role in maintaining trichogenicity.
8 citations
,
June 2022 in “Frontiers in bioengineering and biotechnology” This study found that a collagen patch made with fibroblast-derived extracellular matrix (fdECM) extracted from human lung fibroblasts enhanced wound healing by promoting wound contraction, angiogenesis, and skin remodeling in full-thickness skin wound models, including those with diabetic ulcers.
8 citations
,
July 2017 in “Biochemical and biophysical research communications” This study reported that the pseudoceramide bis-oleamido isopropyl alcohol (BOI) promotes hair growth in ex vivo cultured human hair follicles, likely by enhancing sphingolipid synthesis in dermal papilla cells.
8 citations
,
January 2014 in “Annals of Dermatology” This study found that TGF-β1 expression in follicular tumors correlates with differentiation degree and suggests its potential role alongside p63 in differentiating between sebaceous and follicular tumors.
8 citations
,
January 2015 in “Genetics and Molecular Research” This study found that specific SNPs in the CXCL1 and CXCL2 genes may be associated with increased susceptibility to alopecia areata in the Korean population.
7 citations
,
January 2025 in “Current Issues in Molecular Biology” This study found that PDRN derived from Lactobacillus rhamnosus showed superior antioxidant and wound-healing properties compared to salmon-derived PDRN, while also offering potential benefits in immune modulation and bioavailability.
7 citations
,
March 2022 in “Scientific reports” In this study, researchers found that pigs with genetically disrupted ANTXR1 were resistant to Senecavirus A infection, showing no clinical symptoms, and provided a model for human GAPO syndrome, while confirming ANTXR1 as a receptor for the virus.
7 citations
,
January 2011 in “Veterinary Pathology” In this case report, a 9-year-old horse was diagnosed with alopecia areata contributing to Malassezia dermatitis, involving lymphocyte infiltration and symptoms consistent with yeast presence.
7 citations
,
December 2010 in “대한의생명과학회지” In this study using C57BL/6N mice, the researchers found that skin thickness, mast cell counts, and immunoreactive density of certain cytokines increased at various stages of hair follicle growth following depilation.
6 citations
,
March 2011 in “Experimental Dermatology” This study found that an imbalance of selenium in a C57BL/6 mouse model led to hair loss with color change and was linked with changes in hair follicle apoptosis markers.
5 citations
,
January 2022 in “Molecular Medicine Reports” In this study, topical application of Korean maritime pine bark extract at 2% concentration significantly promoted hair growth in mice, suggesting its potential use for hair loss prevention or treatment.
5 citations
,
January 2011 This study found that Gyungohkgo-gamibang extract and minoxidil both significantly stimulated hair growth and increased hair density and thickness in C57BL/6 mice compared to a vehicle treatment.
4 citations
,
August 2025 in “Journal of Ovarian Research” This study focused on categorizing the research status of natural products for improving ovary and uterus quality, fertility, and weight loss in PCOS, but noted a lack of continuous studies connecting basic research to clinical trials.