The Effect of Gyungokgo-Gamibang Extract on Hair Growth and Protein Expression in Mice

January 2011

Eunju Do, Meeyul Hwang, Seung‐Yeon Kim, Jin-Sang Lee, Dae-Seok Yang, Chae-Ha Yang, Kim Mi-Ryeo

Gyungokgo-gamibang extract YNS-10 minoxidil alopecia hair growth hair density hair thickness IGF-1 VEGF Rogaine

From the encyclopedia

An essential vasodilator with some anti-androgenic effects

Studysummary This study found that Gyungohkgo-gamibang extract and minoxidil both significantly stimulated hair growth and increased hair density and thickness in C57BL/6 mice compared to a vehicle treatment. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the effects of Gyungokgo-gamibang extract (YNS-10) on hair growth and protein expression in C57BL/6 mice with alopecia. Mice were treated with either YNS-10, 5% minoxidil, or a vehicle for 3 weeks. Results showed that both YNS-10 and minoxidil significantly stimulated hair growth, increasing hair density by approximately 210% and 200%, respectively, and hair thickness by about 210% and 220%, respectively, compared to the vehicle. Additionally, the expression of growth factors IGF-1 and VEGF was significantly up-regulated in the YNS-10 and minoxidil groups. The findings suggested that YNS-10 could be a potent ingredient for hair growth treatments.

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Research cited in this study

3 / 3 results

Positive Lymphocyte Transformation Test in a Patient with Allergic Contact Dermatitis of the Scalp After Short-Term Use of Topical Minoxidil Solution

research Positive Lymphocyte Transformation Test in a Patient with Allergic Contact Dermatitis of the Scalp After Short-Term Use of Topical Minoxidil Solution

38 citations , June 2005 in “Contact Dermatitis”

This case report describes a patient with an allergic sensitization to minoxidil, indicating that such patients should pursue alternative therapies to treat androgenetic alopecia.

research Hair Regrowth

118 citations , April 1998 in “Dermatologic Clinics”

This review discusses the advancements in understanding and treating androgenetic alopecia and alopecia areata but reports no clinical findings; the authors emphasize the need for further research on molecular control mechanisms.

research Sulfation of Minoxidil in Keratinocytes and Hair Follicles

19 citations , October 1989 in “PubMed”

This study found that sulfation of minoxidil occurs in hair follicles and proliferative keratinocytes, which may be linked to its hair growth stimulation effects.