11 citations
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January 2024 in “Gynecological Endocrinology” This narrative review on inositol use in PCOS treatment found positive results for myo-inositol alone and effective outcomes for a myo-inositol/D-chiro inositol combination at a 40:1 ratio, suggesting further research on other combinations like 66:1 to 100:1.
8 citations
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August 2011 in “Journal of Medicinal Food” In this study, D-004 did not affect androgen-dependent development in rats exposed in utero, while finasteride caused significant changes in male offspring's androgen-dependent tissues.
7 citations
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January 2009 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that D-004, a hexanic extract from the Cuban royal palm fruit, did not cause genotoxic effects in male germ cells of mice over an 8-week period.
7 citations
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January 1982 in “Acta agriculturae Scandinavica” Mink use L-methionine and L-cystine slightly better than natural amino acids for hair growth, but D-methionine is not effective.
6 citations
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December 2015 in “International journal of nanomedicine” This study found that low-frequency sonophoresis significantly decreased the skin penetration of sodium fluorescein-loaded PEGylated liposomes with D-limonene and affected percutaneous absorption by partially plugging hair follicle orifices.
5 citations
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January 2002 in “European journal of pediatrics” "D-CHRAMPS syndrome" is a newly identified condition with multiple severe symptoms.
3 citations
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November 2022 in “Baghdad Journal of Biochemistry and Applied Biological Sciences” This study found that renin and d-dimer levels were significantly higher in PCOS patients, particularly those also infected with COVID-19, compared to non-PCOS women.
2 citations
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December 2015 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that low frequency sonophoresis may reduce percutaneous absorption of sodium fluorescein-loaded liposomes by partially blocking follicular pathways in the skin.
1 citations
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April 2021 in “International Journal of Research in Dermatology” This study found low serum ferritin and vitamin B12 levels in a significant portion of women with chronic telogen effluvium, while vitamin D deficiency was less common.
1 citations
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January 2022 This study reported that a combination of Myo-inositol and D-chiro-Inositol improved clinical and laboratory parameters in teenage girls with PCOS compared to a placebo.
1 citations
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April 2017 in “Journal of Investigative Dermatology” In this study, D-OCT imaging revealed distinct structural and vascular changes in patients with frontal fibrosing alopecia, highlighting the technique's potential for diagnosing and monitoring the condition's activity.
1 citations
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November 2015 in “Journal of Evolution of Medical and Dental Sciences” This study observed that certain skin symptoms in SLE, such as malar rash and photosensitivity, are linked to systemic involvement, indicating their potential role as markers for disease activity.
1 citations
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July 2012 in “EFSA Journal” The Panel concluded that there is no established cause and effect relationship between the specified vitamin and pumpkin seed oil combination and the maintenance of normal hair in healthy adults.
August 2026 in “Cell Biomaterials” D-chiral biomaterial scaffolds enhance tissue and hair regeneration by activating the body's immune system.
July 2026 in “Research Data Repository, Duke University” This study observed that DMAP scaffolds in a full-thickness wound model promote dermal appendage regeneration by activating humoral immunity, specifically through B cell activation and antibody production, even when adaptive immune cells' infiltration is restricted.
October 2025 in “International Journal of Reproduction Contraception Obstetrics and Gynecology” This study found that Myoinositol and D-chiro inositol treatment improved fertility outcomes in women with PCOS, particularly in Phenotypes A and D, but larger studies are needed to confirm these results.
May 2025 in “Health Science Reports” This study reported that applying Serum WS Biotin, a water-soluble form of D-Biotin, daily for 3 months significantly reduced hair shedding and increased hair strength in volunteers with moderate to excessive hair shedding, while showing good skin compatibility.
December 2023 in “Alzheimer's & dementia” In this rodent study, researchers found that the drug finasteride may reduce anxiety and depression-like behaviors in a model of aging, despite inducing metabolic disturbances and depressive-like behaviors in young rats, suggesting potential considerations for its use in elderly populations.
October 2023 in “International Journal of Cosmetic Science” In this study, researchers developed WS Biotin, a new water-soluble form of biotin, and found that it significantly improves water solubility compared to free biotin and enhances hair-related keratin expression, gene activity for hair growth in vitro, while also reducing melanin content in skin cells.
This review summarizes evidence suggesting that the ratio of Myo-Inositol to D-Chiro-Inositol in follicular fluid is crucial for oocyte and embryo quality.
In this study, subcutaneous injection of mesenchymal stem cell-conditioned medium promoted regeneration of mice skin aged by D-galactose, improving skin thickness, vascularization, and collagen density.
June 2010 in “Seoul National University Open Repository (Seoul National University)” This article discusses the expression of vitamin D receptor in hair follicles and its role in alopecia, without presenting new findings; the authors highlight the involvement of Wnt/b-catenin signaling in hair growth.
January 2010 in “Seoul National University Open Repository (Seoul National University)” This study investigated vitamin D receptor expression in normal hair follicles and those affected by alopecia areata, focusing on various markers using immunohistochemical staining.
January 2007 in “El Servicio de Difusión de la Creación Intelectual (National University of La Plata)” This study found that combining D-004 with finasteride results in more significant prevention of testosterone-induced prostate enlargement in rats compared to using either treatment alone.
July 1999 in “Journal of the American Academy of Dermatology” This review discusses valproic acid as a common antiseizure medication associated with alopecia and highlights the need for its inclusion in relevant medical guides, without presenting new clinical findings.
March 1997 in “Hair transplant forum international” This article discusses Blu Stough's career as the longest full-time practicing hair restoration surgeon in the US and presents no new research findings.
1533 citations
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October 2008 in “Endocrine reviews” This research highlights that engineered mice lacking the vitamin D receptor show multiple health issues similar to human vitamin D deficiency, underscoring the widespread impacts of the vitamin D endocrine system.
1308 citations
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March 1998 in “Journal of bone and mineral research” This review discusses the molecular role of the vitamin D receptor in regulating various biological actions such as bone mineralization and reports no new clinical results, highlighting the complexity of vitamin D's function in multiple tissues.
519 citations
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October 1998 in “Endocrinology” The study found that normalizing mineral ion levels in vitamin D receptor-ablated mice prevented hyperparathyroidism and bone disorders but did not address hair loss, indicating the VDR's role in hair growth.
510 citations
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August 2006 in “Endocrinology” This minireview discusses a proposed model of the vitamin D receptor that explains how 1alpha,25(OH)2D3 can mediate both genomic and rapid responses through different ligand shapes and cellular locations, without presenting new research findings.