Vitamin D Receptor Depletion by Wnt/Beta-Catenin Signaling Caused Alopecia Areata in Human Immunobiology
January 2010
in “
Seoul National University Open Repository (Seoul National University)
”
TLDR Lack of Vitamin D receptors can cause hair loss.
The study explored the role of Vitamin D receptor (VDR) in hair follicles and its connection to alopecia areata (AA). It was found that VDR was expressed in the epidermal component of hair follicles and dermal papilla cells, and its absence led to alopecia. The research involved immunohistochemical staining of human tissue to assess the expression of b-catenin, Wnt3a, Wnt5a, Wnt10b, proliferating cell nuclear antigen (PCNA), involucrin, and filaggrin. The findings suggested that depletion of VDR by Wnt/beta-catenin signaling contributed to the development of alopecia areata.
