The Clinical Evaluation of Serum WS Biotin, a Novel Encapsulated Form of D-Biotin With Improved Water Solubility, for Anti-Hair Shedding Applications. A Prospective Single-Arm, Nonrandomized, Pretest-Posttest Study

    May 2025 in “ Health Science Reports ”
    David González Fernández, Shaher Duchi, L. Béjar … D. A. Goldstein
    Studysummary This study reported that applying Serum WS Biotin, a water-soluble form of D-Biotin, daily for 3 months significantly reduced hair shedding and increased hair strength in volunteers with moderate to excessive hair shedding, while showing good skin compatibility.
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    Research cited in this study 14

    1. The Formulation and In-Vitro Evaluation of WS Biotin, a Novel Encapsulated Form of D-Biotin with Improved Water Solubility for Hair and Skin Treatment Applications International Journal of Cosmetic Science · 2023
    2. Hair Shedding Evaluation for Alopecia: A Refined Wash Test Clinical, Cosmetic and Investigational Dermatology · 2022
    3. The Glypican-1/HGF/C-Met and Glypican-1/VEGF/VEGFR2 Ternary Complexes Regulate Hair Follicle Angiogenesis Frontiers in cell and developmental biology · 2021
    4. Micro-Current Stimulation Has Potential Effects of Hair Growth Promotion on Human Hair Follicle-Derived Papilla Cells and Animal Model International Journal of Molecular Sciences · 2021
    5. The Role of Vitamins and Minerals in Hair Loss: A Review Dermatology and Therapy · 2018
    6. Further Clinical Evidence for the Effect of IGF-1 on Hair Growth and Alopecia Skin appendage disorders · 2017
    7. A Review of the Use of Biotin for Hair Loss Skin appendage disorders · 2017
    8. Prevalence of Hair Shedding Among Women Dermatologic Therapy · 2016
    9. Additional Methods for Diagnosing Alopecia and Appraising Their Severity PubMed · 2014
    10. Increased Rate of Hair Keratin Gene Loss in the Cetacean Lineage BMC Genomics · 2014
    11. Hair Loss in Women: Comprehensive Overview and Treatment Options Seminars in Cutaneous Medicine and Surgery · 2009
    12. Hair Evaluation Methods: Merits and Demerits International Journal of Trichology · 2009
    13. Topical Fulvestrant Solution Has No Effect on Male and Postmenopausal Female Androgenetic Alopecia: Results from Two Randomized, Proof-of-Concept Studies British Journal of Dermatology · 2007
    14. Sequences and Differential Expression of Three Novel Human Type-II Hair Keratins Differentiation · 1997

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