The Clinical Evaluation of Serum WS Biotin, a Novel Encapsulated Form of D-Biotin With Improved Water Solubility, for Anti-Hair Shedding Applications. A Prospective Single-Arm, Nonrandomized, Pretest-Posttest Study

May 2025 in “ Health Science Reports ”

David González Fernández, Shaher Duchi, L. Béjar, María Sala, Akram Hajuj, Danit Molho, Nadeen Abo Saada, D. Martínez, Alejandro Pérez‐Fernández, D. A. Goldstein

Serum WS Biotin D-Biotin hair shedding hair loss hair retention hair thickness biotin water-soluble biotin

TLDR Serum WS Biotin significantly reduces hair shedding and improves hair thickness.

The study investigated the effects of Serum WS Biotin, a novel water-soluble form of D-Biotin, on hair shedding in 22 volunteers with moderate to excessive hair loss over 3 months. Participants used a shampoo with 1.2% WS Biotin daily, and hair shedding was measured at baseline, 1 month, 2 months, and 3 months. Results showed a significant reduction in hair shedding by 43% after 1 month, 56% after 2 months, and 76.1% after 3 months. The treatment also improved hair retention during washing and increased hair thickness. These findings suggest that Serum WS Biotin could be an effective treatment for hair loss, though further research is needed to confirm these results and understand the mechanisms involved. The study was funded by Tagra Biotechnologies.

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The Formulation and In-Vitro Evaluation of WS Biotin, a Novel Encapsulated Form of D-Biotin with Improved Water Solubility for Hair and Skin Treatment Applications

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