Genotoxic Evaluation of D-004 in the Sperm Head Morphology Assay in OF-1 Mice

    January 2009 in “ DOAJ (DOAJ: Directory of Open Access Journals) ”
    Daniel Francisco Arencibia Arrebola, Rafael Gámez Menéndez, Ariadne Gutiérrez Martínez, Balia Pardo Acosta, Miriam Noa Puig, Rosa Más Ferreiro, Dayisell Curveco Sánchez, Haydeé García Cambián, Edy Goicochea Carrero
    TLDR D-004 did not harm sperm cells in mice.
    The study evaluated the genotoxic effects of D-004, an extract from the Cuban royal palm, on sperm head morphology in OF-1 mice. Over 8 weeks, four groups of 10 mice each were given different doses of D-004 (500, 1,000, and 1,500 mg/kg) or a control solvent. The results showed no significant differences in sperm concentration or the frequency of normal and abnormal sperm among the groups. Additionally, there was no mortality or clinical signs of toxicity observed. The study concluded that D-004 did not exhibit genotoxic potential on male germ cells in mice during spermatogenesis.
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