Effects of In Utero Exposure to D-004, a Lipid Extract from Roystonea Regia Fruits, in the Male Rat: A Comparison with Finasteride

    December 2011 in “ Journal of Medicinal Food ”
    Ariadne Gutiérrez Martínez, Balia Pardo, Rafael Gámez, Rosa Más, Miriam Noa, Gisela Marrero, Maikel Valle, Haydee García, Dayisell Curveco, Nilda Mendoza, E. Goicochea
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    TLDR D-004 may be a natural alternative to finasteride for treating enlarged prostate and male baldness.
    The study investigated the effects of in utero exposure to D-004, a lipid extract from Roystonea regia fruits, on male rats and compared it to the effects of finasteride. The results showed that D-004 did not cause any alterations in androgen-dependent development, while exposure to finasteride during late gestation resulted in a permanent reduction in anogenital distance and retention of nipples in adult male rats. D-004 had similar effects to finasteride in reducing the weight of the prostate gland and seminal vesicles, as well as decreasing the levels of dihydrotestosterone. The study suggests that D-004 may have potential as a natural alternative to finasteride for the treatment of benign prostatic hyperplasia and male pattern baldness.
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