Effects of In Utero Exposure to D-004, a Lipid Extract from Roystonea Regia Fruits, in the Male Rat: A Comparison with Finasteride

December 2011 in “ Journal of Medicinal Food ”

Ariadne Gutiérrez Martínez, Balia Pardo, Rafael Gámez, Rosa Más, Miriam Noa, Gisela Marrero, Maikel Valle, Haydee García, Dayisell Curveco, Nilda Mendoza, E. Goicochea

D-004 lipid extract Roystonea regia finasteride androgen-dependent development anogenital distance retention of nipples prostate gland seminal vesicles dihydrotestosterone benign prostatic hyperplasia male pattern baldness Propecia DHT BPH

TLDR D-004 may be a natural alternative to finasteride for treating enlarged prostate and male baldness.

The study investigated the effects of in utero exposure to D-004, a lipid extract from Roystonea regia fruits, on male rats and compared it to the effects of finasteride. The results showed that D-004 did not cause any alterations in androgen-dependent development, while exposure to finasteride during late gestation resulted in a permanent reduction in anogenital distance and retention of nipples in adult male rats. D-004 had similar effects to finasteride in reducing the weight of the prostate gland and seminal vesicles, as well as decreasing the levels of dihydrotestosterone. The study suggests that D-004 may have potential as a natural alternative to finasteride for the treatment of benign prostatic hyperplasia and male pattern baldness.

View this study on liebertpub.com →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research Inhibitors of 5α-Reductase in the Treatment of Benign Prostatic Hyperplasia

52 citations, February 2006 in “Current pharmaceutical design”

5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.

research The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia

1707 citations, December 2003 in “The New England Journal of Medicine”

Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.

research Effects of In Utero Exposure to Finasteride on Androgen-Dependent Reproductive Development in Male Rats

118 citations, May 2003 in “Toxicological Sciences”

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

research Critical Developmental Periods for Effects on Male Rat Genitalia Induced by Finasteride, a 5α-Reductase Inhibitor

86 citations, March 1993 in “Toxicology and Applied Pharmacology”

Finasteride affects male rat genitalia development, causing abnormalities during specific pregnancy days.

Related Community Posts Join

6 / 1000+ results

community My personal experience/observations fighting AGA seriously for 5 years

in Treatment 43 upvotes 2 weeks ago

Minoxidil with alcohol and propylene glycol was more effective than non-alcohol versions, and RU58841 worked best in a non-water-based solution. Oral finasteride showed better results than topical, despite side effects; microneedling and tretinoin worsened hair loss, and PRP was only helpful when younger.

community Finasteride and minoxidil Dec 1st to may 10th

in Is this regrowth? 392 upvotes 7 months ago

The conversation is about someone's progress with hair regrowth using finasteride and minoxidil from December 1st to May 10th. They also mention using a topical treatment with a concentration of 0.004 per spray.

community Thoughts on topical dut, changing protocol starting next week

in Finasteride/Dutasteride 5 upvotes 1 month ago

A user shared a new hair loss treatment protocol including topical dutasteride, latanoprost, caffeine, minoxidil, tretinoin, and triamcinolone acetonide. Others discussed the effectiveness and availability of these treatments, with some suggesting simpler oral alternatives.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 411 upvotes 2 weeks ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community Bryan Johnson used a customized formula by Roots byGA to restore his hair

in Treatment 23 upvotes 1 month ago

Bryan Johnson used a customized hair restoration formula from Roots byGA, which includes Minoxidil, Cetirizine HCl, Latanoprost, Dutasteride, Melatonin, Caffeine, Tretinoin, Vitamin D3, and Vitamin E. Many users are skeptical of the effectiveness and uniqueness of the treatment, suggesting that standard treatments like Minoxidil and Dutasteride are more reliable.

community Anyone try a combo therapy of everything except fin? Minox + Tret + microneedling + caffeine, etc

in Chat 1 upvotes 3 months ago

The user experienced severe side effects from finasteride and is considering a combination therapy including Minoxidil, Tretinoin, microneedling, caffeine, and other ingredients. They are also thinking about adding red light therapy and microneedling once per week.

Related Research

3 / 3 results

research Low-Dose In Utero Exposure to Finasteride Promotes Developmental Changes in Both Male and Female Gerbil Prostates

1 citations, August 2019 in “Environmental Toxicology”

Exposure to low doses of finasteride in the womb causes changes in the prostate of both male and female gerbils.

research Effects of In Utero Exposure to Finasteride on Androgen-Dependent Reproductive Development in Male Rats

118 citations, May 2003 in “Toxicological Sciences”

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

research Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men

30 citations, August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride doesn't affect hormone levels in normal men.