Low-Dose In Utero Exposure to Finasteride Promotes Developmental Changes in Both Male and Female Gerbil Prostates

August 2019 in “ Environmental Toxicology ”

Juliana S. Maldarine, Bruno Domingos Azevedo Sanches, Vitória A. Santos, Gustavo Matheus Amaro, Marília Freitas Calmon, Paula Rahal, Rejane Maira Góes, Patrícia Simone Leite Vilamaior, Sebastião Roberto Taboga

finasteride androgen receptor estrogen-α receptor periductal smooth muscle stromal proliferation Propecia

TLDR Exposure to low doses of finasteride in the womb causes changes in the prostate of both male and female gerbils.

The study conducted by researchers from the State University of Campinas and São Paulo State University in Brazil in 2019 investigated the effects of low-dose intrauterine exposure to finasteride on postnatal prostate development in male and female Mongolian gerbils. The study found that even at low dosages, finasteride exposure led to changes in both male and female prostates. In female gerbils, it caused a thickening of periductal smooth muscle and increased stromal proliferation. The study also found sex differences in the impact of exposure on the expression of the androgen receptor, which was increased in males, and of the estrogen-α receptor, which was decreased in the male prostate but unchanged in females.

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