research Sp6 Downregulation of Follistatin Gene Expression in Ameloblasts
Sp6 promotes tooth development by reducing follistatin levels.
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research Wnt Signaling Activation: Targets and Therapeutic Opportunities for Stem Cell Therapy and Regenerative Medicine
Wnt activation shows promise for regenerative medicine but requires selective targeting to minimize risks like cancer.
research Simultaneous Quantitation of Nine Hydroxy-Androgens and Their Conjugates in Human Serum by Stable Isotope Dilution Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry
A new method accurately measures nine specific hormones in human blood.
research Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.
research Molecular Genetics of Alopecias
Scientists have found specific genes linked to different hair loss conditions, which could lead to new treatments.
research Inactivation of Autophagy Leads to Changes in Sebaceous Gland Morphology and Function
Autophagy is crucial for normal sebaceous gland function and sebum composition.
research Topical Delivery of Protein and Peptide Using Novel Cell Penetrating Peptide IMT-P8
The peptide IMT-P8 can effectively deliver proteins into the skin and cells for potential skin treatments.
research The Potential Application of Nanocarriers in Delivering Topical Antioxidants
Nanocarriers can improve antioxidant delivery to the skin but face safety and production challenges.
research The Fraser Complex Proteins Can Form Anchoring Cords Without AMACO at the Dermal-Epidermal Junction of Mouse Skin
Certain skin proteins can form anchoring structures without the protein AMACO.
research Angiogenin Is Expressed in Human Dermal Papilla Cells and Stimulates Hair Growth
Angiogenin helps hair grow by stimulating cell growth and blood vessel formation.
research Effect of Carbamates on mRNA Encoding Lipid Enzymes in Hamster Flank Organs
Carbamates may help treat androgen-dependent conditions by changing how certain lipid enzymes are produced.
research Biological Activity of Novel Progesterone Derivatives Having Bulky Ester Side Chains at C-3
The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.
research Cutaneous Androgen Metabolism: Basic Research And Clinical Perspectives
Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.
research Alopecia Areata: Pathogenesis And Treatment
No single treatment is consistently effective for alopecia areata, and more research is needed.
research A Single-Arm, Open-Label, Phase Ib Clinical Study Evaluating the Efficacy and Safety of Durvalumab in Combination with Albumin-Bound Paclitaxel and Carboplatin as Neoadjuvant Therapy for Resectable Stage III Non-Small Cell Lung Cancer
The treatment showed high response rates and was well-tolerated, potentially extending patient survival.
research A Genome-Wide Association Study of Chemotherapy-Induced Alopecia in Breast Cancer Patients
A specific gene variant is linked to a higher risk of hair loss from chemotherapy in breast cancer patients.
research Janus Kinase Inhibitors: An Innovative Treatment for Alopecia Areata
New medicines that block a specific pathway are showing promise for treating severe hair loss but need more testing for safety and effectiveness.
research Recent Advances in the Pathogenesis of Autoimmune Hair Loss Disease Alopecia Areata
Alopecia areata is caused by immune system attacks on hair follicles, often triggered by viral infections.
research Refinement of Technique in Injection Lipolysis Based on Scientific Studies and Clinical Evaluation
Injection lipolysis effectively reduces small fat deposits and should be done with care and proper patient selection.
research Understanding Autoimmunity of Vitiligo and Alopecia Areata
Both vitiligo and alopecia areata involve an immune response triggered by stress and specific genes, with treatments targeting this pathway showing potential.
research Malignancy and Cancer Treatment-Related Hair and Nail Changes
Hair and nail changes can indicate health issues, including cancer and side effects from cancer treatments.
research Drug-Induced Hair Loss
Naproxen is not the cause of hair loss in a child; it's due to a toxic event with expected hair regrowth.
research Cytostatics and Immunosuppressive Drugs: Toxicities and Management
Some cancer and immune system drugs can cause serious side effects, including heart, lung, nerve, and organ damage, which need careful monitoring and management.
research Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide
Scientists made the first metal-based compounds from a nonsteroidal antiandrogen drug, which showed potential in fighting both hormone-dependent and independent prostate cancer cells.
research Identification of Drug-Specific Public TCR Driving Severe Cutaneous Adverse Reactions
Researchers found a specific immune receptor in patients that causes severe skin reactions to a drug.
research Atrophic Telogen Effluvium from Cytotoxic Drugs and a Randomized Controlled Trial to Investigate the Possible Protective Effect of Pretreatment with a Topical Vitamin D3 Analogue in Humans
Topical vitamin D3 does not prevent hair loss from chemotherapy.
research HaCaT Cell Proliferation Influenced by Melatonin
Melatonin affects skin cell growth differently based on how much and how long it's used.
research The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients
Certain immune cells contribute to severe hair loss in chronic alopecia areata, with Th17 cells possibly having a bigger impact than cytotoxic T cells.
research Cutaneous Drug Reactions
Any drug can cause skin reactions, but antibiotics, NSAIDs, and psychotropic drugs are more common, with some reactions being life-threatening.
research Selective Expansion of Tregs Using the IL-2 Cytokine Antibody Complex Does Not Reverse Established Alopecia Areata in C3H/HeJ Mice
Increasing Treg cells in the skin does not cure hair loss from alopecia areata in mice.