Refinement of Technique in Injection Lipolysis Based on Scientific Studies and Clinical Evaluation

The document from 2009 presents findings from several studies on injection lipolysis, a technique for reducing localized fat deposits. One study with six female volunteers aged 25 to 60 showed that a phosphatidylcholine (PC) and sodium deoxycholate (DC) solution induced fat necrosis without immediate cytotoxic reactions, while DC alone caused intense inflammatory changes and fibrosis. Another study involving adipose tissue from five human subjects and 12 cats found that deoxycholate alone was responsible for adipocyte cell death, and more injection sessions led to greater weight and girth loss in cats. A multicenter clinical trial with 17 human volunteers demonstrated high satisfaction and modest reduction in skin fold thickness, indicating the technique's effectiveness for topographic contour correction. The document concludes that injection lipolysis is a finesse procedure suitable for small fat deposits, with sodium deoxycholate as the active component causing adipocyte lysis, and emphasizes the importance of patient selection and managing expectations.