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Certain HSD3B1 gene types are linked to worse prostate cancer outcomes and affect treatment response and other health conditions.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

Modulating Cytochrome P450 activity could help develop new skin disease treatments.

Human skin produces sex hormones like estrogen and testosterone, influenced by ARO and StAR, which may affect skin elasticity and hair growth.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

Genetics play a role in acne, but how exactly they contribute is not fully understood.

Topical patidegib gel effectively treats basal cell carcinoma in Gorlin syndrome patients without causing the side effects seen with oral treatments.

Overactive Wnt signaling in mouse skin stem cells causes acne-like cysts and shrinking oil glands, which some treatments can partially fix.

Eicosanoids are crucial for skin health, and targeting their pathways may help treat skin conditions.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

Genetic differences within ethnic groups may affect prostate cancer treatment effectiveness.

Certain drugs that block specific enzymes can help treat prostate diseases.

Removing REDD1 in mice increases skin fat by making fat cells larger and more numerous.

New understanding and treatments for hair loss are improving, but more research is needed.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Frontal Fibrosing Alopecia's cause is unclear, affects mainly postmenopausal women, and current treatments focus on stopping hair loss rather than regrowth.

Trilostane may help delay epilepsy development by increasing certain brain chemicals.

Activating Nrf2 in skin cells causes skin disease similar to chloracne in mice.

The conclusion is that endocrinology significantly impacts medicine with various common medications used for treatment.

Pregnenolone might help manage movement issues caused by Parkinson's disease treatment without reducing the medicine's effectiveness.

Activating TSPO helps protect the retina from damage caused by high eye pressure in glaucoma.

Honokiol helps protect skin from damage and aging caused by cigarette smoke.