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    Glossary Cyclosporine

    immunosuppressive drug used to prevent organ rejection and treat autoimmune diseases

    Cyclosporine, also known as cyclosporin A or CsA, is an immunosuppressive drug primarily used to prevent organ transplant rejection and to treat certain autoimmune conditions. It works by inhibiting the activity of T-cells, a type of white blood cell involved in the immune response. In dermatology, cyclosporine has been explored for its potential to treat severe cases of alopecia areata, a condition characterized by sudden hair loss.

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    1. The use of cyclosporine in dermatology: Part I Journal of the American Academy of Dermatology · 2010 · 131 citations
    2. A Murine Model for Inducing and Manipulating Hair Follicle Regression (Catagen): Effects of Dexamethasone and Cyclosporin A Journal of Investigative Dermatology · 1994 · 124 citations
    3. Toxicity of the immune suppressant cyclosporin A in the rat The Journal of Pathology · 1982 · 116 citations
    4. Cyclosporin A: a new drug in the field of canine dermatology Veterinary Dermatology · 2004 · 84 citations
    5. Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles PLOS Biology · 2018 · 68 citations
    6. Cyclosporin: applications in small animal dermatology Veterinary Dermatology · 2003 · 59 citations
    7. Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes American Journal of Physiology-cell Physiology · 2003 · 57 citations
    8. Cyclosporin A stimulates hair growth in nude mice. PubMed · 1987 · 55 citations
    9. Treatment of alopecia areata in the DEBR model using Cyclosporin A lipid vesicles. PubMed · 2004 · 54 citations
    10. Hair growth-stimulating effects of cyclosporin A and FK506, potent immunosuppressants Journal of Dermatological Science · 1994 · 54 citations
    11. Cyclosporin A Promotes Hair Epithelial Cell Proliferation and Modulates Protein Kinase C Expression and Translocation in Hair Epithelial Cells Journal of Investigative Dermatology · 2001 · 45 citations
    12. Three cases of immune‐mediated adnexal skin disease treated with cyclosporin Veterinary Dermatology · 2006 · 36 citations
    13. Differences in activity of minoxidil and cyclosporin A on hair growth in nude and normal mice. Comparisons of in vivo and in vitro studies. PubMed · 1990 · 35 citations
    14. Partial Response of Severe Alopecia areata to Cyclosporine A Dermatology · 1999 · 30 citations
    15. Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles Journal of Investigative Dermatology · 2015 · 29 citations
    16. Hair Growth on Nude Mice Due to Cyclosporin A The Journal of Dermatology · 1991 · 25 citations
    17. Topical application of cyclosporin A induces rapid-remodeling of damaged anagen hair follicles produced in cyclophosphamide administered mice Journal of Dermatological Science · 2001 · 24 citations
    18. Alopecia areata presenting in 2 kidney-pancreas transplant recipients taking cyclosporine Journal of The American Academy of Dermatology · 2005 · 23 citations
    19. Ovarian function after renal transplantation: comparison of cyclosporin A with azathioprine and prednisone combination regimens BJOG An International Journal of Obstetrics & Gynaecology · 1984 · 21 citations
    20. Combination Therapy with Cyclosporine and Psoralen Plus Ultraviolet A in the Patients with Severe Alopecia Areata: A Retrospective Study with a Self-Controlled Design 2013 · 21 citations
    21. Exfoliative cutaneous lupus erythematosus in German shorthaired pointer dogs: disease development, progression and evaluation of three immunomodulatory drugs (ciclosporin, hydroxychloroquine, and adalimumab) in a controlled environment Veterinary Dermatology · 2010 · 21 citations
    22. Does Cyclosporin A Influence Sex Hormone Level? Experimental and Clinical Endocrinology & Diabetes · 2009 · 20 citations
    23. Effects of immunosuppressive peptidyl-prolyl cis-trans isomerase (PPIase) inhibitors, cyclosporin A, FK506, ascomycin and rapamycin, on hair growth initiation in mouse: immunosuppression is not required for new hair growth Journal of Dermatological Science · 1995 · 20 citations
    24. Cyclosporine Archives of Dermatology · 1990 · 20 citations
    25. (5) Topical cyclosporin A in alopecia totalis: failure of therapeutic effect due to lack of penetration 1989 · 16 citations
    26. A Comparative Study of Oral Cyclosporine and Betamethasone Minipulse Therapy in the Treatment of Alopecia Areata 2016 · 14 citations
    27. Comparison of High-Dose Corticosteroid Pulse Therapy and Combination Therapy Using Oral Cyclosporine with Low-Dose Corticosteroid in Severe Alopecia Areata 2015 · 14 citations
    28. Identification of a Cyclosporine-Specific P450 Hydroxylase Gene through Targeted Cytochrome P450 Complement (CYPome) Disruption in Sebekia benihana Applied and Environmental Microbiology · 2013 · 13 citations
    29. Utility of azathioprine, methotrexate and cyclosporine as steroid‐sparing agents in chronic alopecia areata: a retrospective study of continuation rates in 138 patients 2020 · 12 citations
    30. Alopecia areata in a renal transplant recipient on cyclosporin Australasian journal of dermatology · 1996 · 12 citations