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GlossaryCalcineurin Inhibitors

medications that suppress immune response by blocking calcineurin activity

Calcineurin inhibitors (CNIs) are a class of medications that suppress the immune system by blocking the activity of calcineurin, a protein involved in activating T-cells. They are commonly used to prevent organ transplant rejection and to treat autoimmune diseases. In dermatology, CNIs like tacrolimus and pimecrolimus are used topically to manage conditions such as atopic dermatitis and certain types of alopecia, as they help reduce inflammation and immune response in the skin.

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research The Many Faces of Calcineurin Inhibitor Toxicity—What the FK?

97 citations, January 2020 in “Advances in chronic kidney disease”

Calcineurin inhibitors, used in kidney transplants, can cause a wide range of side effects including kidney damage and other health issues.

research Update on the Use of Topical Calcineurin Inhibitors in Cutaneous Lupus Erythematosus

9 citations, February 2011 in “Biologics: Targets & Therapy”

Topical calcineurin inhibitors, especially 0.1% tacrolimus ointment, are effective and well-tolerated for treating cutaneous lupus erythematosus but require more research for standard treatment guidelines.

Scalp Atrophy Secondary to Steroid Use in Patients With Scarring Alopecia: Are Topical Steroids Superior to Topical Calcineurin Inhibitors?

research Scalp Atrophy Secondary to Steroid Use in Patients With Scarring Alopecia: Are Topical Steroids Superior to Topical Calcineurin Inhibitors?

1 citations, November 2023 in “International Journal of Dermatology”

Topical calcineurin inhibitors might be safer than steroids for scarring alopecia, but more research is needed.

research Calcineurin/Nuclear Factor of Activated T-Cell Pathway in Cutaneous Squamous Cell Carcinoma

August 2019 in “International journal of dermatology and venereology”

The calcineurin/NFAT pathway plays a significant role in the development and growth of a type of skin cancer called cutaneous squamous cell carcinoma.

research Update on Frontal Fibrosing Alopecia

2 citations, April 2017 in “Actas Dermo-Sifiliográficas”

Best treatment for Frontal Fibrosing Alopecia is 5-alpha-reductase inhibitors and intralesional corticosteroids.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 828 upvotes 5 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.