Topical Cyclosporin A Treatment in Psoriasis and Other Dermatological Diseases: Theoretical and Practical Aspects

The document reviewed the potential of topical cyclosporin A (CyA) as a treatment for various dermatological diseases, including psoriasis, alopecia, contact and atopic dermatitis, oral lichen planus, and keloid scars. While systemic administration of CyA was effective, its long-term use was limited by renal side effects. The review highlighted the theoretical advantage of topical application, which could target affected areas directly and potentially reduce systemic side effects. It also discussed the pharmacokinetics of CyA when applied topically, suggesting a promising alternative to oral administration for managing these skin conditions.