Cyclosporine

    March 1990 in “ Archives of Dermatology ”
    Jean Kanitakis
    TLDR Nonimmunosuppressive cyclosporines might treat skin diseases by affecting cell growth.
    Cyclosporine, an immunosuppressant targeting CD4+ T lymphocytes, was found to directly affect the growth of various epithelial cell types. It stimulated hair follicle keratinocytes, leading to hypertrichosis, while exerting a cytostatic effect on other epithelial cells. This antiproliferative property was also observed in some cyclosporine analogues with minimal or no immunosuppressive effects, indicating different molecular mechanisms for epithelial cell growth modulation and immunosuppression. This discovery suggested potential for using nonimmunosuppressive cyclosporines in treating hyperproliferative epidermal diseases.
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      community how to compound topical cyclosporine

      in Treatment  9 upvotes 2 years ago
      The conversation is about compounding topical cyclosporine for hair loss, suggesting it needs an oil base like castor oil. The user seeks tips or tricks for the process.

      community What happened to the 40mg dutasteride daily and Cyclosporine dude?

      in Chat  40 upvotes 1 week ago
      A user previously claimed to take 40mg of dutasteride daily and planned to try Cyclosporine, but their account and comments have since been deleted, raising concerns about their well-being. Other users discussed the risks and effectiveness of high doses of dutasteride, with some sharing their own experiences using dutasteride, finasteride, and minoxidil for hair loss treatment.

      community Forgotten 'Total Revival' Stack

      in Research/Science  42 upvotes 2 months ago
      Cyclosporine A is discussed as a powerful hair growth stimulant, potentially more effective than minoxidil, but concerns about safety and side effects, including cancer risk, limit its use. The conversation highlights the need for further research and experimentation with topical application, despite its risks.

      community Starting Way-316606 for the first time today.

      in Research/Science  30 upvotes 3 months ago
      A user is experimenting with a homemade solution of WAY-316606 for hair regrowth, combining it with other treatments like minoxidil and dutasteride. The community expresses concern over the safety and mental health implications of such drastic measures, with mixed opinions on the effectiveness of WAY-316606.

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