Cyclosporine

    March 1990 in “ Archives of Dermatology ”
    Jean Kanitakis
    TLDR Nonimmunosuppressive cyclosporines might treat skin diseases by affecting cell growth.
    Cyclosporine, an immunosuppressant targeting CD4+ T lymphocytes, was found to directly affect the growth of various epithelial cell types. It stimulated hair follicle keratinocytes, leading to hypertrichosis, while exerting a cytostatic effect on other epithelial cells. This antiproliferative property was also observed in some cyclosporine analogues with minimal or no immunosuppressive effects, indicating different molecular mechanisms for epithelial cell growth modulation and immunosuppression. This discovery suggested potential for using nonimmunosuppressive cyclosporines in treating hyperproliferative epidermal diseases.
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