Topical Cyclosporin A in Alopecia Totalis: Failure of Therapeutic Effect Due to Lack of Penetration
TLDR Topical cyclosporin A doesn't work for alopecia totalis because it doesn't penetrate the skin well.
The study titled "Topical cyclosporin A in alopecia totalis: failure of therapeutic effect due to lack of penetration" published in July 1989 in the British Journal of Dermatology concluded that topical application of cyclosporin A was ineffective in treating alopecia totalis. The primary reason for this failure was identified as the lack of adequate penetration of the drug into the skin. This finding highlighted the importance of drug delivery methods in the effectiveness of topical treatments for hair loss conditions.
