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Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

Stem cell self-renewal is complex and needs more research for full understanding.

Rosa multiflora root extracts may help promote hair growth and have anti-aging benefits.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.

Compartmentalized organization might be crucial for stem cells to effectively respond to growth or injury.

Hair follicle regeneration in skin grafts may be possible using stem cells and tissue engineering.

PBX1 reduces aging and cell death in stem cells by boosting SIRT1 and lowering PARP1.

Thyroid hormones are important for skin health and changes in them can affect conditions like hair loss and eczema.

Caraway, Chinese chives, and cassia may improve health and prevent diseases due to their nutrients and medicinal properties.

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

The document explains how to create detailed biological pathways using genomic data and tools, with examples of hair and breast development.

Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.

Hair grays due to oxidative stress and fewer functioning melanocytes.

Using 448-kHz Capacitive-Resistive Electrothermal Therapy can help increase hair density and prevent hair loss in women.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Gene therapy, especially using atoh1, shows promise for creating functional sensory hair cells in the inner ear, but dosing and side effects need to be managed for clinical application.

Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.

Non-coding RNAs are important for hair growth and could lead to new hair loss treatments, but more research is needed.

AA–TF#15 significantly promotes hair regrowth and could be an effective treatment for androgenic alopecia.

Myristoleic acid helps hair growth by boosting cell growth and recycling processes in hair follicle cells.

Chemotherapy-induced hair loss is partly due to decreased laminin-511 and increased laminin-332.

The peach gene CTG134 helps control the interaction between auxin and ethylene, which could lead to new agricultural chemicals.

WWOX deficiency in mice causes skin and fat tissue problems due to disrupted cell survival signals.

YH0618 helps reduce chemotherapy-induced hair loss by targeting specific proteins and pathways.

Intermediate filaments are crucial for cell differentiation and stem cell function.

HSPGs help control stem cell behavior, affecting hair growth and offering a target for hair loss treatments.