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Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.

Histone modification is key in treating chronic inflammatory skin diseases.

Substances from Chinese medicines show promise for immune support and disease prevention, but the way they are processed affects their effectiveness.

Hair proteins have weak spots in their α-helical segments.

Keratin is crucial for keeping skin cells healthy and its changes can lead to diseases and affect cell behavior.

Colorectal cancer development involves both genetic changes and epigenetic alterations like DNA methylation and microRNA changes.

Scientists made human hair magnetic by coating it with special nanoparticles.

Diet changes can protect against harmful environmental effects on fetal development.

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

Hair and nail cells share similar proteins, indicating a common differentiation pathway.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Jumonji genes are important for development and their mutations can cause abnormalities, especially in the heart and brain.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

Both drugs lower DHT levels, with GI198745 being more effective.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Calcium is important for stem cell function and maintenance, especially in blood and skin cells.

C-reactive protein helps monocytes stick to blood vessel cells by causing oxidative stress.

Researchers found an RNA transcript that might help control a growth factor linked to tumor development.

L-PGDS has specific binding sites for its functions and could help in drug delivery system design.

Wnt3a protein, when packed in liposomal vesicles, can stimulate hair growth and could potentially treat conditions like hair loss.

Chromosomal changes, including those in the WRN gene and rDNA, may significantly contribute to aging.

Low oxygen areas help maintain and protect blood stem cells by using a simple sugar breakdown process for energy and managing their activity levels.

Biotin and biotinidase are essential to prevent health issues, and deficiencies require lifelong supplementation.

Cholesterol-modified siRNAs targeting certain genes increased hair growth in mice.

Polycystic ovary syndrome and iron overload share similar symptoms and can be potentially treated with blood removal, diet changes, and probiotics.