39 citations
,
August 2022 in “Cell Death and Disease” This study found that a dopamine-methacrylated hyaluronic acid hydrogel enhances the efficacy of adipose-derived stem cells in promoting skin regeneration, potentially involving the Notch signaling pathway.
39 citations
,
September 2016 in “Expert Opinion on Drug Delivery” This review explores how colloidal drug delivery systems can enhance the stability, absorption, and bioavailability of phytochemicals, potentially rediscovering ancient compounds' therapeutic benefits and overcoming limitations like poor solubility and bioavailability.
33 citations
,
December 2012 in “NMR in Biomedicine” This study reports that microencapsulation of therapeutic cells with contrast agents enables visualization across multiple imaging modalities, potentially improving cellular immunoprotection and tracking after transplantation.
32 citations
,
June 2017 in “Journal of Pharmaceutical Sciences” This study found that coating liquid crystalline nanoparticles with chitosan significantly enhanced the skin permeation of 5α-reductase inhibitors, suggesting a promising strategy for improving topical delivery in androgenetic alopecia treatment.
28 citations
,
January 2017 in “Critical Reviews in Therapeutic Drug Carrier Systems” This review classifies engineered nanomaterials by composition and application in biomedicine, highlighting diverse uses like regenerative medicine and potential occupational side effects, but reports no new clinical results.
26 citations
,
June 2020 in “Polymers” This study reported that a magneto-responsive transdermal microneedle system delivered Minoxidil effectively and significantly increased hair density by 800% in mice with androgenetic alopecia after 10 days.
24 citations
,
October 2019 in “Biomaterials Research” This study investigated the use of Minoxidil encapsulated in HA-PLGA nanoparticles for alopecia treatment and found that these nanoparticles efficiently delivered the drug to hair follicle cells without significant cytotoxicity, offering a potential transdermal delivery method for various diseases.
23 citations
,
January 2022 in “Biomaterials Science” Non-viral vectors show promise for safe and effective CRISPR/Cas9 gene editing in treating diseases.
23 citations
,
February 2021 in “Journal of Endocrinological Investigation” This review discusses the impact of COVID-19 on the endocrine system and reports no clinical results; the authors emphasize the need to investigate endocrine damage during and after COVID-19 infection.
21 citations
,
January 2019 in “Elsevier eBooks” The authors suggest that nanoparticles, synthesized from biological sources, may enable targeted cancer therapy with fewer side effects than traditional methods.
19 citations
,
April 2024 in “Journal of Umm Al-Qura University for Applied Sciences” This review explores the diverse roles of rosemary, covering its nutritional and medicinal uses, cosmetic and pharmaceutical applications, and evaluates various extraction methods, with a focus on sustainable practices and commercial prospects.
18 citations
,
February 2023 in “PLoS ONE” This study developed a triple drug delivery system using nanoparticles loaded with 5-fluorouracil, curcumin, and piperine to target breast tumors, demonstrating notable in vitro cytotoxicity and anti-metastatic potential in 3D tumor spheroids which suggests its promise for further preclinical evaluation.
17 citations
,
August 2024 in “Discover Nano” This review summarizes that polyesters hold promise for vascular tissue engineering due to their mechanical properties and biodegradability, but optimizing their use in repairing damaged blood vessels remains challenging due to the complexity of vascular tissues.
17 citations
,
January 2023 in “Nanoscale Advances” The microneedle arrays effectively promote wound healing and have potential for clinical use.
17 citations
,
April 2017 in “International Journal of Biological Macromolecules” This study found that alginate beads containing monoolein demonstrated promising potential for managing wet wounds by better absorbing excess exudate and delivering adenosine locally, favoring drug localization in damaged porcine skin compared to an aqueous solution without affecting skin viability.
16 citations
,
August 2014 in “Archives of Pharmacal Research” This study found that surface-modified liquid crystalline nanoparticles significantly enhanced skin permeation of finasteride and dutasteride compared to unmodified nanoparticles, suggesting potential for improved treatment efficacy in androgenetic alopecia.
15 citations
,
January 2020 in “ACS Applied Materials & Interfaces” This study reported that a novel chitosan/polyvinyl alcohol nanofiber sponge effectively enhances the hair follicle-inducing ability of dermal papilla multicellular spheroids in a mouse model.
13 citations
,
October 2012 in “InTech eBooks” Nanocarriers could improve how drugs are delivered through the skin but require more research to overcome challenges and ensure safety.
10 citations
,
January 2024 in “Polymer Chemistry” This review discusses the design and advances of lipid–polymer hybrid nanoparticles as promising delivery systems for genome editing strategies, highlighting their potential in biomedical applications.
10 citations
,
January 2016 in “Elsevier eBooks” This chapter reviews the role of nanoparticles in wound healing, exploring current therapies, developments, and future directions, but reports no new clinical results.
9 citations
,
October 2018 in “Elsevier eBooks” This article discusses how challenges in drug development and success rates are driving a shift in the pharmaceutical industry towards engineering targeted drug delivery systems, with nanomaterials offering potential solutions for selective therapeutic delivery.
8 citations
,
January 2021 in “Pharmaceutics” This study found that using nanoporous silica entrapped lipid-drug complexes enhanced the solubility and bioavailability of dutasteride in beagle dogs.
8 citations
,
November 2020 in “Optics and Laser Technology” This review discusses the applications and advantages of LED-based photobiomodulation therapy for dermatological and cosmetic purposes but highlights existing challenges and health concerns while exploring future perspectives.
5 citations
,
February 2024 in “Frontiers in bioengineering and biotechnology” This research review outlines the challenges of diabetic wounds, such as diabetic foot ulcers, and examines the potential of electrospinning nanofiber scaffolds to improve healing by promoting tissue formation, allowing drug release, and enhancing specific wound healing properties.
4 citations
,
July 2025 in “International Journal of Nanomedicine” This review explores nano-quercetin formulations to enhance the solubility, stability, and targeted delivery of quercetin, highlighting its potential efficacy in treating cancer, inflammation, metabolic diseases, and tissue regeneration, though challenges in biocompatibility, toxicity, and production remain, per this source.
4 citations
,
January 2022 in “Current pharmaceutical design” This review discusses the benefits and applications of microsponges delivery systems in drug delivery, particularly for topical treatments, and reports no new clinical findings.
4 citations
,
September 2020 in “Annals of Translational Medicine” This study found that concentrated nanofat, used alone or with decellularized nanofat, may enhance hair growth in mice by activating dermal papilla cells and the anagen phase.
3 citations
,
October 2021 in “Letters in Applied NanoBioScience” This article explores the integration of nanotechnology and cosmetics, highlighting the development of cosmeceuticals targeting issues such as wrinkling, hyperpigmentation, and skin dehydration, while also reviewing cosmetic history and types of nanotechnology by particle size.
3 citations
,
April 2018 in “Therapeutic Delivery” This editorial discusses advances in engineering techniques for hair follicle regeneration and highlights future potential but reports no original research findings.
2 citations
,
May 2021 in “Journal of pharmaceutical and biomedical analysis” This study utilized a UHPLC-HRMS method to identify eight active pharmaceutical ingredients, such as ketoconazole and minoxidil, in 26 out of 100 analyzed cosmetic products.