June 2024 in “Computational and Structural Biotechnology Journal” This review discusses the integration of omics analyses in androgenetic alopecia research, reporting no new clinical results but suggesting that collaborative multi-omics studies may enhance understanding of AGA's pathomechanisms.
May 2024 in “JAMA Dermatology” In this study, researchers identified genetic factors associated with frontal fibrosing alopecia, noting a protective effect of a specific CYP1B1 gene variant, which may offer insights into the disease's pathogenesis and future risk mitigation strategies.
February 2026 in “International Journal of Molecular Sciences” In this study, researchers identified 47 proteins associated with male pattern baldness severity and prioritized five candidate genes, including druggable CD38, suggesting new non-hormonal targets for therapeutic development.
January 2026 in “International Journal of Molecular Sciences” This narrative review highlights that declining testosterone levels are a complex public health issue potentially influenced by modifiable lifestyle factors and environmental stressors, suggesting integrated strategies may be needed to address the trend's impacts on health.
March 2025 in “Nature Communications” This study used human stem cell-derived skin organoids to model EV-A71 infection, revealing that various skin cell types are susceptible to the virus and identifying a potential drug target and replication inhibitor, suggesting its utility for studying skin infectious diseases and drug screening.
March 2024 in “BMC women's health” This study found that free testosterone levels were 29% higher with the levonorgestrel implant than with the DMPA injection, which may impact sexual function, mood, and side effects like acne.
July 2023 in “The Journal of Clinical Endocrinology and Metabolism” This narrative review suggests that, after at least two years of gender-affirming hormone therapy, nonathletic transgender individuals tend to have physical performance levels similar to cisgender individuals, though more controlled research is necessary, particularly among trans athletes.
17 citations
,
May 2020 in “Forensic Science International Genetics” This study found that genetically variant peptides from human hair can reliably identify individuals despite differences in age and storage conditions, provided environmental and processing factors are controlled.
380 citations
,
February 2023 in “Journal of Clinical Medicine” This review discusses various potential risk factors and possible therapeutic interventions for polycystic ovary syndrome, including the modulation of gut microbiota, but reports no new findings.
234 citations
,
November 2009 in “American journal of human genetics” This study identified genetic variants in the Trichohyalin gene that account for approximately 6% of the variance in hair morphology among Australians of European descent.
214 citations
,
April 2017 in “Cell” This study found that micro-niches within hair follicles create heterogeneity among stem cells and transit-amplifying cells, leading to specialized progenitors that control tissue morphogenesis and regeneration.
207 citations
,
July 2006 in “Development” This study identified a novel MTS24-positive murine keratinocyte population with increased colony-forming ability, suggesting these cells may serve as a new reservoir of proliferative progenitor or stem cells in hair follicles.
200 citations
,
March 2023 in “Nature Reviews Molecular Cell Biology” This review discusses the role and regulation of quiescent adult stem cells in tissue maintenance and repair, focusing on molecular mechanisms and their implications for regenerative medicine, but reports no new clinical results.
170 citations
,
January 2010 in “animal” This review discusses the biology of hair follicles across various species and their role in fiber quality, but reports no new experimental findings.
138 citations
,
August 2020 in “Frontiers in Endocrinology” This review discusses expert consensus on PCOS, emphasizing its impacts and supporting evidence-based treatments, while recommending further research into nutraceutical benefits for managing the condition; it reports no new clinical results.
130 citations
,
April 2003 in “Journal of Investigative Dermatology” This study reports the cloning and expression details of two new human type II keratins, K6irs3 and K6irs4, in the hair follicle's inner root sheath, suggesting a distinct functional role related to hair structure.
114 citations
,
March 2010 in “Zebrafish” This review discusses the use of the zebrafish lateral line system as a model to study hair cell loss, protection, and regeneration, with potential implications for human hearing research.
106 citations
,
June 2009 in “BMC Genomics” This study identified specific gene expression profiles during the intestinal regeneration of sea cucumbers, highlighting potential novel genes and advancing the understanding of regenerative biology in echinoderms.
87 citations
,
September 2006 in “Clinical Cancer Research” This article reviews the diverse roles of protein kinase C (PKC) isozymes in cancer biology, highlighting their potential as therapeutic targets, but reports no new experimental results.
86 citations
,
May 2002 in “Journal of Investigative Dermatology” This study characterized a new human keratin, hK6irs1, specifically found in the inner root sheath of hair follicles, which suggests its role in the structural integrity and guidance of growing hair shafts.
70 citations
,
September 2017 in “Expert opinion on therapeutic patents” This review examines the patent literature on AKR1C3 inhibitors and suggests that although numerous potent inhibitors exist, further preclinical optimization is necessary before assessing their therapeutic potential in human diseases.
54 citations
,
January 2009 in “Development” This study concluded that Wnt/β-catenin signaling, through Shh and Bmp pathways, is crucial for determining hair follicle fate in embryonic epidermal development.
52 citations
,
August 2021 in “Microorganisms” This review observes higher ACE2 expression in myocardial and lung tissues of heart failure and COPD patients but finds no link between RAAS inhibitors and COVID-19 severity.
49 citations
,
December 2022 in “Pharmacological Reviews” This review discusses androgen receptor targeting as a potential treatment strategy for triple-negative breast cancer and reports no new experimental outcomes.
47 citations
,
July 2023 in “Nature Genetics” 44 citations
,
April 2023 in “Frontiers in Molecular Biosciences” This narrative review outlines the diverse symptoms and possible mechanisms behind long COVID, such as immune dysregulation and viral persistence, while discussing ongoing and potential treatments, highlighting the current lack of proven effective therapies.
44 citations
,
September 2020 in “International Journal of Molecular Sciences” This review discusses the disruption of hormonal and metabolic rhythms in polycystic ovary syndrome and explores potential drug targets to address its molecular causes, without providing new clinical results.
37 citations
,
April 2021 in “Nutrients” This study found that berberine supplementation improved gut microbiota composition and reduced obesity-related hepatic inflammation and oxidative stress in genetically obese mice.
37 citations
,
August 2020 in “BMC Genomics” This study found that while genetic variants contribute minimally to predicting hair greying in a Polish population, age remains the primary predictor, underscoring the complexity of hair greying as a genetic trait.
36 citations
,
October 2021 in “Frontiers in Endocrinology” This study highlights the importance of understanding the roles of hyperandrogenemia and insulin resistance in the development and progression of PCOS, emphasizing further research to clarify their mutual influence.