The Impact of Angiotensin-Converting Enzyme 2 Expression Levels in Patients with Comorbidities on COVID-19 Severity: A Comprehensive Review

    August 2021 in “ Microorganisms ”
    Rui Calejo Rodrigues, Sofia Costa‐de‐Oliveira
    Studysummary This review observes higher ACE2 expression in myocardial and lung tissues of heart failure and COPD patients but finds no link between RAAS inhibitors and COVID-19 severity.
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    Research cited in this study 3

    1. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Cell Stem Cell · 2020
    2. Racial Variations in COVID-19 Deaths May Be Due to Androgen Receptor Genetic Variants Associated with Prostate Cancer and Androgenetic Alopecia. Are Anti-Androgens a Potential Treatment for COVID-19? Journal of Cosmetic Dermatology · 2020
    3. ACE2 and TMPRSS2 Potential Involvement in Genetic Susceptibility to SARS-CoV-2 in Cancer Patients Cell Transplantation · 2020