82 citations
,
July 2012 in “Brain pathology” This study found that LGR5 may play a significant role in maintaining brain cancer stem-like cells and is associated with glioma progression and poor outcomes.
54 citations
,
October 2022 in “Cells” This review discusses the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles and modern technologies like 3D bioprinting but reports no new clinical results.
47 citations
,
June 2015 in “Contact Dermatitis” This review discusses the need for an updated 'European hair cosmetic series' to include common contact allergens and remove outdated substances based on current evidence and regulations, but it reports no new results.
33 citations
,
January 2018 in “Blood” This study found that topical ruxolitinib protected Lgr5+ skin stem cells and maintained skin homeostasis in skin GVHD, unlike corticosteroids.
26 citations
,
July 2021 in “Frontiers in Cell and Developmental Biology” This review discusses mesenchymal stromal cell-conditioned medium for various skin conditions and found improvements in wound healing, hair restoration, and more, but emphasizes the need for further research to validate these findings.
26 citations
,
June 2016 in “Frontiers in Plant Science” This study describes a method to isolate and analyze young and mature type VI trichomes from wild tomato species using autofluorescence-based cell sorting.
20 citations
,
April 2019 in “BioMed Research International” This study found that DNA hypermethylation was present in melasma lesions, and treatments with sunscreen, niacinamide, and retinoic acid were associated with decreased methylation and clinical improvement.
10 citations
,
February 2018 in “Royal Society Open Science” This study found that a shampoo containing quaternized wheat protein hydrolysate can effectively improve hair recovery by smoothing and compacting damaged hair surfaces, thanks to modifications that enhance protein adherence and disulfide bond formation at pH levels typical in hair care products.
6 citations
,
April 2022 in “Biomedicine & pharmacotherapy” This review discusses the potential of using triads of repositioned medicines targeting multiple pathogenic mechanisms to prevent or delay retina degeneration, but reports no new results.
5 citations
,
May 2023 in “Frontiers in Immunology” This review provides an overview of how advancing imaging technologies, such as tissue clearing and intravital microscopy, are enhancing our understanding of tumor architecture and interactions between cancer cells and the tumor microenvironment, aiding both fundamental cancer research and the development of therapies.
4 citations
,
January 2025 in “International Journal of Molecular Sciences” This study found that progesterone and its metabolite, allopregnanolone, provided anti-anxiety and anti-depressive effects in female mice, potentially independent of nuclear progestin receptors but requiring 5α-reduction and estradiol's influence on brain-derived neurotrophic factor.
4 citations
,
April 2021 in “Majalah Farmasetika” This review discusses formulations and evaluation of herbal shampoos for hair growth stimulation, finding licorice extract shampoo to be the most effective, and reports no new clinical results.
3 citations
,
November 2022 in “International journal of molecular sciences” This study reported that bio-pulsed avian-derived mesenchymal stem cell extracellular vesicles significantly improved cell proliferation, wound healing, and gene expression in human skin fibroblasts and hair follicle cells.
3 citations
,
May 2018 in “Journal of nutritional health & food science” This review discusses the potential of a low-dose comprehensive cyclical nutrient therapy for enhancing hair growth and strengthening hair roots, but reports no new experimental results.
2 citations
,
June 2025 in “Molecules” This review highlights that extracts from *Hamamelis virginiana* (witch hazel) exhibit antimicrobial, anti-inflammatory, antioxidant, and wound-healing properties in various studies, showing promise for future therapeutic use in dermatology and cosmetology, particularly for skin treatments.
2 citations
,
April 2025 in “Cells” This study found that heat preconditioning of nanofat from mice did not improve tissue vascularization or integration in grafting, and actually reduced vascularization due to increased expression of anti-angiogenic factors, suggesting it is not beneficial for enhancing its vascularization properties.
2 citations
,
May 2024 in “Australasian Journal of Dermatology” Early diagnosis, innovative treatments, and considering systemic conditions are crucial in dermatological care.
1 citations
,
November 2025 in “Stem Cell Research & Therapy” This study developed immortalized human hair follicle-derived mesenchymal-like stromal cells (iHF-MSCs) as a consistent source of therapeutic secretome, reporting their superior immunomodulatory and regenerative performance, potentially advancing cell-free therapies for inflammation and tissue repair.
1 citations
,
August 2025 in “Biology Direct” This review discusses the evolution of adipose tissue research in regenerative medicine, from tissue transfer to cell-free bioengineering applications, highlighting its therapeutic potential, current limitations, and future directions.
1 citations
,
March 2025 in “Molecular Medicine Reports” This review discusses the potential therapeutic effects of exosomes from various cell sources in treating acute kidney injury and explores their mechanisms, but reports no new clinical results.
1 citations
,
January 2025 in “Molecules” This review reported that while glycyl-L-histidyl-L-lysine tripeptide copper complex (GHK–Cu) has limited skin permeation when used alone, liposomes may enhance its absorption, but there is limited research on this aspect, highlighting a need for further studies.
1 citations
,
August 2024 in “Journal of Pharmacy & Pharmaceutical Sciences” This study found that forming inclusion complexes of DPCP with HPβCD using the 3D ground mixture method enhances its anti-inflammatory activity at lower doses compared to complexes with β-CD.
1 citations
,
June 2023 in “Cells” This review highlights exosomes as a promising treatment for skin damage from UV light, infrared radiation, burns, and disorders due to their anti-inflammatory properties, ability to induce macrophage polarization, and acceleration of skin repair and regeneration.
This study found that hypoxic preconditioning of nanofat from donor mice reduced its vascularization capacity in vivo, suggesting that this approach cannot currently enhance nanofat's regenerative potential.
January 2026 in “Dermatologic Therapy” This review discusses folliculotropic mycosis fungoides, highlighting its diagnostic criteria and therapeutic strategies based on disease staging, but does not report new clinical findings.
December 2025 in “Current Issues in Molecular Biology” In this systematic review, animal studies showed that cytarabine causes multi-organ toxicities, notably neurotoxicity, linked to oxidative stress and other mechanisms, though study quality raises concerns about reliability and translation to human outcomes.
December 2025 in “Aesthetic Surgery Journal” This study reviews the role of exosomes in regenerative aesthetics, highlighting their potential in treating conditions like photoaging and wound healing through mechanisms like matrix remodeling and immunomodulation, while also noting advancements in exosome isolation techniques and regulatory considerations.
This study found that fibroblasts from Emery-Dreifuss muscular dystrophy patients with certain genetic mutations overexpress markers of fibrosis, and gene correction techniques reduced fibrogenic molecule expression in cell models, suggesting potential therapeutic applications.
January 2025 in “Antioxidants” In this study, repetitive subcutaneous administrations of a conditioned medium from stem cells significantly suppressed hair graying in mice exposed to X-ray irradiation, likely through antioxidative mechanisms involving HGF and potentially VEGF.
August 2024 in “Indian Journal of Skin Allergy” This review outlines the current state of stem cell therapy in dermatology, highlighting its potential for treating a variety of skin disorders and conditions, while emphasizing the need for further controlled studies to standardize treatment and fully understand its efficacy and limitations.