Unraveling Translational Insights Into Systemic Multi-Organ Toxicity of Cytosine Arabinoside (Ara-C): A Systematic Review of Preclinical Animal Evidence

    December 2025 in “ Current Issues in Molecular Biology
    Ioannis Konstantinidis, Sophia Tsokkou, Antonios Keramas … Theodora Papamitsou
    Studysummary In this systematic review, animal studies showed that cytarabine causes multi-organ toxicities, notably neurotoxicity, linked to oxidative stress and other mechanisms, though study quality raises concerns about reliability and translation to human outcomes.
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    Research cited in this study 6

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    2. Characterization and Management of Adverse Events of Low-Dose Oral Minoxidil Treatment for Alopecia: A Narrative Review Journal of Clinical Medicine · 2025
    3. The Alpha-Lipoic Acid Derivative Sodium Zinc Dihydrolipoylhistidinate Reduces Chemotherapy-Induced Alopecia in a Rat Model: A Pilot Study Surgery today · 2011
    4. The Effect of Active Hexose Correlated Compound in Modulating Cytosine Arabinoside-Induced Hair Loss, and 6-Mercaptopurine- and Methotrexate-Induced Liver Injury in Rodents Cancer epidemiology · 2009
    5. Protection Against Cytosine Arabinoside-Induced Alopecia by Minoxidil in a Rat Animal Model International Journal of Dermatology · 1995
    6. Treatment with ImuVert and N-Acetylcysteine Protects Rats from Cyclophosphamide and Cytarabine-Induced Alopecia Cancer investigation · 1992