The Effect of Active Hexose Correlated Compound in Modulating Cytosine Arabinoside-Induced Hair Loss, and 6-Mercaptopurine- and Methotrexate-Induced Liver Injury in Rodents

August 2009 in “ Cancer epidemiology ”

Bo Sun, Koji Wakame, Eri Sato, Hiroshi Nishioka, Okezie I. Aruoma, H. Fujii

Active Hexose Correlated Compound cytosine arabinoside alopecia 6-mercaptopurine methotrexate AHCC Ara-C 6-MP MTX

TLDR AHCC reduces hair loss and liver injury caused by chemotherapy in rodents.

The study investigated the effects of Active Hexose Correlated Compound (AHCC) on chemotherapy-induced side effects in rodents, finding that AHCC significantly reduced alopecia in neonatal rats treated with cytosine arabinoside (Ara-C) and ameliorated liver injury in mice treated with 6-mercaptopurine (6-MP) and methotrexate (MTX). AHCC improved body weight, blood cell counts, liver function, and enzyme activities, suggesting its potential to mitigate chemotherapy-induced side effects and improve patients' quality of life. Further research was recommended to understand its molecular mechanisms and clinical applicability.

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Research cited in this study

4 / 4 results

research Chemoprevention of Smoke-Induced Alopecia in Mice by Oral Administration of L-Cystine and Vitamin B6

41 citations, March 2007 in “Journal of dermatological science”

Taking L-cystine and vitamin B6 can prevent hair loss caused by smoke in mice.

research Clinical Approach to the Patient With Alopecia

21 citations, March 2006 in “Seminars in Cutaneous Medicine and Surgery”

Most hair loss disorders can be accurately diagnosed and treated in an outpatient setting.

research Disorders of Hair in Infants and Children Other Than Alopecia

13 citations, January 2002 in “Clinics in dermatology”

A mushroom extract might reduce hair loss and liver damage caused by certain chemotherapy drugs in animals.

Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone

research Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone

36 citations, April 1994 in “PubMed”

Cyclosporine A slows down hair loss from chemotherapy in mice, while dexamethasone increases hair loss but speeds up regrowth.

The Effect of Active Hexose Correlated Compound in Modulating Cytosine Arabinoside-Induced Hair Loss, and 6-Mercaptopurine- and Methotrexate-Induced Liver Injury in Rodents

Research cited in this study

research Chemoprevention of Smoke-Induced Alopecia in Mice by Oral Administration of L-Cystine and Vitamin B6

research Clinical Approach to the Patient With Alopecia

research Disorders of Hair in Infants and Children Other Than Alopecia

research Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone

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