Immortalized Human Hair Follicle-Derived Mesenchymal-Like Stromal Cells for Long-Term Production of Scalable Immunomodulatory and Regenerative Secretome
November 2025
in “
Stem Cell Research & Therapy
”
immortalized human hair follicle-derived mesenchymal-like stromal cells iHF-MSCs mesenchymal stromal cells regenerative secretome immunomodulatory secretome peripheral blood mononuclear cells regulatory T cells conditioned media cell proliferation cell migration tube formation antioxidant properties oxidative stress hyperglycemia-induced damage hair follicle stem cells MSC immune modulation regenerative medicine antioxidants
Studysummary This study developed immortalized human hair follicle-derived mesenchymal-like stromal cells (iHF-MSCs) as a consistent source of therapeutic secretome, reporting their superior immunomodulatory and regenerative performance, potentially advancing cell-free therapies for inflammation and tissue repair.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This study demonstrates the potential of immortalized human hair follicle-derived mesenchymal-like stromal cells (iHF-MSCs) for scalable production of immunomodulatory and regenerative secretomes. The research highlights the successful immortalization of HF-MSCs, particularly clones C18 and C26, which maintain multipotency and exhibit strong immunomodulatory capabilities by suppressing peripheral blood mononuclear cell proliferation and enhancing regulatory T cell induction. The iHF-MSC-derived conditioned media promotes cell proliferation, migration, and tube formation, showcasing regenerative potential. Additionally, these cells exhibit antioxidant properties, protecting against oxidative stress and hyperglycemia-induced damage. The findings suggest that iHF-MSCs could be a valuable resource for therapeutic applications in regenerative medicine, inflammatory, and oxidative stress-related disorders.
