Immortalized Human Hair Follicle-Derived Mesenchymal-Like Stromal Cells for Long-Term Production of Scalable Immunomodulatory and Regenerative Secretome

    November 2025 in “ Stem Cell Research & Therapy ”
    Maria Rossello-Gelabert, Kevin Las Heras, Ainhoa Gonzalez‐Pujana … Rosa Marı́a Hernández
    Studysummary This study developed immortalized human hair follicle-derived mesenchymal-like stromal cells (iHF-MSCs) as a consistent source of therapeutic secretome, reporting their superior immunomodulatory and regenerative performance, potentially advancing cell-free therapies for inflammation and tissue repair.
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    Research cited in this study 7

    1. Dermal Papilla Cells: From Basic Research to Translational Applications Biology · 2024
    2. Stimulation by Exosomes from Hypoxia-Preconditioned Hair Follicle Mesenchymal Stem Cells Facilitates Mitophagy by Inhibiting the PI3K/AKT/mTOR Signaling Pathway to Alleviate Ulcerative Colitis Theranostics · 2024
    3. Extracellular Vesicles Released by Hair Follicle and Adipose Mesenchymal Stromal Cells Induce Comparable Neuroprotective and Anti-Inflammatory Effects in Primary Neuronal and Microglial Cultures Cytotherapy · 2023
    4. Extracellular Vesicles from Hair Follicle-Derived Mesenchymal Stromal Cells: Isolation, Characterization, and Therapeutic Potential for Chronic Wound Healing Stem cell research & therapy · 2022
    5. Human Hair Follicle-Derived Mesenchymal Stromal Cells from the Lower Dermal Sheath as a Competitive Alternative for Immunomodulation Biomedicines · 2022
    6. Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-Conditioning Frontiers in Immunology · 2018
    7. Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine International Journal of Molecular Sciences · 2017