Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Hematopoiesis in Mouse Cultures

August 2018 in “ Stem cells international ”

Jun Li, Claire A. Higgins, Jenna C. Whitehouse, Susan J. Harris, Heather Crawford, Angela M. Christiano, Majlinda Lako, Nicholas Hole, Colin A. B. Jahoda

hair follicle dermal cells dermal papilla cells dermal sheath cells embryonic stem cells induced pluripotent stem cells haematopoietic stem cells cytokines stromal support pluripotent cells feeder cells DP cells DS cells ESCs iPSCs HSCs

TLDR Hair follicle cells help maintain and support stem cells and blood cell formation.

The study demonstrated that hair follicle dermal cells (HFDCs) could support the expansion and long-term maintenance of both murine and human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) in an undifferentiated state. HFDCs expressed high levels of pluripotency markers and secreted cytokines such as LIF, CNTF, and CT-1, which are crucial for maintaining stemness. Additionally, HFDCs promoted haematopoiesis in mouse cultures, suggesting their potential as a valuable resource for stem cell research and therapy, including applications in alopecia treatment and skin grafts.

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Research cited in this study

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research STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction

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Hair growth can be stimulated by combining certain skin cells, which can rejuvenate old cells and cause them to specialize in hair follicle creation.

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Research cited in this study

research STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

research The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

research Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth

research Reprogramming of Human Hair Follicle Dermal Papilla Cells into Induced Pluripotent Stem Cells

research Transformation of Amnion Epithelium into Skin and Hair Follicles

research Two Distinct Signaling Pathways in Hair Cycle Induction: Stat3-Dependent and Independent Pathways

research Hair Matrix Germinative Epidermal Cells Confer Follicle-Inducing Capabilities on Dermal Sheath and High Passage Papilla Cells

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