Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Hematopoiesis in Mouse Cultures

August 2018 in “ Stem cells international ”

Jun Li, Claire A. Higgins, Jenna C. Whitehouse, Susan J. Harris, Heather Crawford, Angela M. Christiano, Majlinda Lako, Nicholas Hole, Colin A. B. Jahoda

hair follicle dermal cells dermal papilla cells dermal sheath cells embryonic stem cells induced pluripotent stem cells haematopoietic stem cells cytokines stromal support pluripotent cells feeder cells DP cells DS cells ESCs iPSCs HSCs

TLDR Hair follicle cells help maintain and support stem cells and blood cell formation.

The study demonstrated that hair follicle dermal cells (HFDCs) could support the expansion and long-term maintenance of both murine and human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) in an undifferentiated state. HFDCs expressed high levels of pluripotency markers and secreted cytokines such as LIF, CNTF, and CT-1, which are crucial for maintaining stemness. Additionally, HFDCs promoted haematopoiesis in mouse cultures, suggesting their potential as a valuable resource for stem cell research and therapy, including applications in alopecia treatment and skin grafts.

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STAT5 activation is crucial for starting the hair growth phase.

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