Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Hematopoiesis in Mouse Cultures

    August 2018 in “ Stem cells international ”
    Jun Li, Claire A. Higgins, Jenna C. Whitehouse … Colin A. B. Jahoda
    Studysummary This study found that cultured hair follicle dermal cells support maintenance and potentially aid in the clinical application of pluripotent and haematopoietic stem cells.
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    Research cited in this study 15

    1. Hair Follicle-Derived Mesenchymal Cells Support Undifferentiated Growth of Embryonic Stem Cells Experimental and Therapeutic Medicine · 2017
    2. STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction Journal of Investigative Dermatology · 2016
    3. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    4. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    5. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    6. Reprogramming of Human Hair Follicle Dermal Papilla Cells into Induced Pluripotent Stem Cells Journal of Investigative Dermatology · 2012
    7. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice Journal of Investigative Dermatology · 2011
    8. Comparative Characterization of Hair Follicle Dermal Stem Cells and Bone Marrow Mesenchymal Stem Cells Stem Cells and Development · 2006
    9. Cultured Cells From the Adult Human Hair Follicle Dermis Can Be Directed Toward Adipogenic and Osteogenic Differentiation Journal of Investigative Dermatology · 2005
    10. Transdifferentiation of Corneal Epithelium Into Epidermis Occurs by Means of a Multistep Process Triggered by Dermal Developmental Signals Proceedings of the National Academy of Sciences · 2005
    11. Transformation of Amnion Epithelium into Skin and Hair Follicles Differentiation · 2004
    12. Hair Follicle Dermal Cells Differentiate Into Adipogenic and Osteogenic Lineages Experimental Dermatology · 2003
    13. Two Distinct Signaling Pathways in Hair Cycle Induction: Stat3-Dependent and Independent Pathways Proceedings of the National Academy of Sciences of the United States of America · 2000
    14. Hair Matrix Germinative Epidermal Cells Confer Follicle-Inducing Capabilities on Dermal Sheath and High Passage Papilla Cells Development · 1996
    15. The Secret Life of the Hair Follicle Trends in genetics · 1992