1 citations
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April 2017 in “Journal of Investigative Dermatology” In this study, D-OCT imaging revealed distinct structural and vascular changes in patients with frontal fibrosing alopecia, highlighting the technique's potential for diagnosing and monitoring the condition's activity.
159 citations
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November 2007 in “American Journal of Pathology” In this study, researchers found that substance P triggered premature catagen development and immune changes in human scalp hair follicles, providing a possible biological link between stress and hair loss conditions like telogen effluvium and alopecia areata.
67 citations
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January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This review discusses telogen effluvium, a common type of hair loss, focusing on differentiation from other conditions and potential causes, but presents no new research findings.
55 citations
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September 2017 in “Expert Opinion on Drug Discovery” This review examines the main absorption sites and influencing factors for orally administered drugs, highlighting variables such as solubility and gastrointestinal conditions that affect drug absorption in the small intestine and the development of effective drug delivery systems.
26 citations
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January 2017 in “Acta dermato-venereologica” This review examines the use of monoaminergic antidepressants for inflammatory skin disorders and reports they may reduce dermatological symptoms, suggesting a potential role beyond treating psychiatric conditions.
22 citations
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October 2012 in “Journal of Investigative Dermatology” This study found that C57BL/6 mice with a diet containing specific levels of vitamin A showed alterations in retinoid metabolism and increased frequency of cicatricial alopecias, suggesting dietary factors may play a role in this condition.
21 citations
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January 2002 in “Journal of Cutaneous Medicine and Surgery” This study reports that finasteride treatment in men with androgenetic alopecia appears to restore caspase and XIAP expression in hair follicles to levels similar to those in individuals without the condition.
9 citations
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May 2005 in “Expert Review of Clinical Immunology” This article examines anticytokine therapies for autoimmune diseases, highlighting the potential of anti-interferon-γ as a universal treatment for certain conditions and noting varying effectiveness of tumor necrosis factor-α inhibitors.
7 citations
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November 2013 in “Pediatric and Developmental Pathology” This retrospective review of hair samples from pediatric patients indicated that microscopic hair examination might be a useful first-line investigation for diagnosing various genetic conditions.
2 citations
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September 2023 in “Frontiers in molecular biosciences” This review highlights the potential of targeting hepatic stellate cell ferroptosis as a treatment strategy for liver fibrosis, underscoring the need for further research into ferroptosis mechanisms in these cells to better understand and combat this condition.
1 citations
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September 2018 in “Australasian Journal of Dermatology” In this report, a 2-year-old male with GAPO syndrome exhibited androgenetic-like alopecia with normal testosterone levels and telogen hair loss, which are novel findings for this condition.
June 2026 in “Frontiers in Immunology” This review synthesizes both traditional and emerging molecular mechanisms of tissue remodeling across different organs, aiming to establish a theoretical basis for precision interventions in pathological conditions, according to the authors.
August 2025 in “Frontiers in Immunology” This meta-analysis found that patients with alopecia areata, particularly those with more extensive forms like alopecia totalis and universalis, may face a higher risk of cardiovascular disease, though no links were found with specific conditions like ischemic stroke or myocardial infarction.
September 2024 in “African Journal of Biomedical Research” This study found that individuals with alopecia areata had significantly lower blood levels of vitamin D and slightly lower serum copper levels compared to healthy controls, suggesting the potential importance of assessing these factors in the chemical evaluation of patients with this condition.
April 2024 in “Cell death and differentiation” This study discusses how different modes of regulated cell death in keratinocytes affect skin stem cell niches, and their role in skin inflammation, injury repair, and cancer, based on findings from human dermatological conditions and experimental mouse models.
March 2024 in “GSC Advanced Research and Reviews” This study observed that exposure to different wavelengths of light affects opsin and clock gene responses in skin cells, suggesting potential therapeutic approaches using photobiomodulation for dermatological conditions like psoriasis and wound healing.
February 2024 in “Scientific reports” This study identified four ferroptosis-related genes, SLC40A1, LCN2, CREB5, and SLC7A11, as potential diagnostic markers for alopecia areata, revealing reduced expression in affected patients compared to controls, with a predictive model showing high accuracy in differentiating the condition.
January 2024 in “Frontiers in immunology” This review highlights the crucial role of histone modification in the pathogenesis and treatment of chronic inflammatory skin diseases, and explores therapeutic strategies targeting these epigenetic changes to improve management of conditions such as psoriasis and atopic dermatitis.
September 2023 in “Frontiers in medicine” This review suggests that the mTOR signaling pathway may play a significant role in hair follicle health by influencing the effects of Vitamin D receptor deficiency, potentially contributing to hair follicle damage and related hair loss conditions.
August 2022 in “Frontiers in genetics” This study identified a novel bi-allelic missense variant in the DSC3 gene linked to severe Hypotrichosis with Recurrent Skin Vesicles in a Saudi child, supporting its role in the condition.
February 2022 in “Global academic journal of medical sciences” This study observed lower vitamin D levels in alopecia areata patients compared to healthy controls and suggested a possible causal role of vitamin D deficiency in the condition.
November 2022 in “Journal of Investigative Dermatology” This study found that MPZL3 knockout mice showed reduced dermal white adipose tissue and increased sebocyte proliferation, suggesting a regulatory role for MPZL3 in lipid metabolism balance between adipocytes and sebocytes.
29 citations
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June 2015 in “Kidney International” This study developed a kidney-specific knockout mouse model lacking the Flcn gene, which recapitulates human Birt-Hogg-Dubé kidney tumorigenesis and shows that mTOR pathway inhibition with rapamycin can suppress tumor growth.
30 citations
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September 2016 in “Aging Cell” This study found that selenium deficiency in mice accelerated age-related conditions and metabolic decline but unexpectedly promoted longevity, suggesting low selenium levels might separate healthspan and lifespan.
3 citations
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April 2025 in “Science Advances” This study found that mice with a homozygous knockout of the Ten1 gene, developed through CRISPR-Cas9-mediated exon 3 deletion, exhibited telomere shortening and symptoms consistent with accelerated aging, such as reduced lifespan, skin changes, aplastic anemia, and cerebellar hypoplasia.
45 citations
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September 2012 in “The Journal of Steroid Biochemistry and Molecular Biology” This study found that deleting β-catenin in epidermis-specific VDR knockout mice did not prevent UVB-induced skin tumors, indicating β-catenin does not compensate for VDR's role in tumor suppression.
180 citations
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January 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that vitamin D receptor knockout mice exhibit impaired epidermal differentiation and progressive hair loss, suggesting the importance of the vitamin D receptor in normal skin and hair follicle development.
18 citations
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March 2016 in “Journal of Investigative Dermatology” This study found that calbindin-D9k knockout mice on a maternal vitamin D-deficient and low-calcium diet developed transient alopecia, but a high-vitamin D and calcium diet in mothers reduced this effect.
14 citations
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November 2019 in “Mediators of inflammation” This study found that adipose-derived stem cell-conditioned media improved skin flap survival following ischemia/reperfusion injury in mice by increasing cell proliferation and the number of hair follicles, mediated by IL-6.
2 citations
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May 2019 in “International Journal of Molecular Sciences” This study suggests that in gp91phox-knockout mice, tranexamic acid administration led to brown hair by increasing MGRN1 and collagen XVII levels, while the retention of black hair appears to rely on the gp91phox/ROS/IL-1β/TGF-β pathway.