266 Myristoylphorbol Acetate (MPA) Enhances Metastasis Via Up-Regulation of Eph A2 Transcription Activity

July 2012 in “ European journal of cancer ”

C. Liu, Wen‐Chung Tsai, Jianhua Ruan, Ho Joon Chang

aE-catenin aT-catenin keratinocyte hyperproliferation hair cycle transition partial baldness a-catenin protein switches hair cycle baldness

TLDR MPA increases cancer spread by boosting Eph A2 activity.

The study investigated the functional differences and overlaps between aE-catenin and aT-catenin in vivo using conditional transgenic mice. By replacing aE-catenin with aT-catenin in specific organs, researchers observed that aT-catenin could rescue the lethal phenotype caused by aE-catenin knockout in skin, characterized by keratinocyte hyperproliferation and pre-cancerous lesions. However, the transgenic mice experienced recurrent partial baldness due to issues in hair cycle transition, indicating potential functional discrepancies or insufficient a-catenin levels. The findings provided proof-of-principle for further experiments on a-catenin protein switches in carcinoma models.

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community M22 Shedding recovery fin 1mg min 1ml

in Finasteride/Dutasteride 142 upvotes 11 months ago

A user shared their experience with hair loss treatment using finasteride (1mg) and minoxidil (1ml), noting significant shedding phases but hoping for improvement. Shedding is a common synchronized effect of the treatment, which may desynchronize over time, potentially taking over 5 years.

community Minoxidil, Fin and Cetirizine.

in Treatment 6 upvotes 2 years ago

The user started a hair care routine using 0.5mg finasteride daily, 2ml of 5% minoxidil, and 4.5mg of cetirizine topically to address hair loss. They plan to provide updates and are also interested in cetirizine's potential to reduce scalp itching and redness due to its anti-inflammatory properties.

community Efficacy of different dutasteride doses vs finasteride

in Research/Science 123 upvotes 1 year ago

Dutasteride doses matter for hair loss treatment and are more effective than finasteride. RU58841 is suggested for better gains, but side effect profiles should be considered.

community Oral Minoxidil Users In A Nutshell

in Satire 1211 upvotes 2 years ago

This conversation is about hair loss treatments, specifically oral minoxidil and finasteride. Users discussed the potential side effects of using these drugs, as well as their experiences with them.

community 1 year fin 1mg and minox. can see some density reclaimed

in Update 562 upvotes 3 years ago

User shared 1-year progress using finasteride 1mg and minoxidil, regaining hair density. Others praised the improvement and asked about side effects and additional treatments.

community Real world data from Europe shows that DUT is significantly safer than FIN in long term use

in Research/Science 529 upvotes 1 month ago

Dutasteride is safer than finasteride for long-term use, with fewer sexual side effects. Users experience better hair regrowth and fewer side effects with dutasteride.

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research Eph Receptors and Ephrins: Therapeutic Opportunities

222 citations, October 2014 in “Annual Review of Pharmacology and Toxicology”

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.