266 Myristoylphorbol Acetate (MPA) Enhances Metastasis Via Up-Regulation of Eph A2 Transcription Activity

July 2012 in “ European journal of cancer ”

C. Liu, Wen‐Chung Tsai, Jianhua Ruan, Ho Joon Chang

aE-catenin aT-catenin keratinocyte hyperproliferation hair cycle transition partial baldness a-catenin protein switches hair cycle baldness

TLDR MPA increases cancer spread by boosting Eph A2 activity.

The study investigated the functional differences and overlaps between aE-catenin and aT-catenin in vivo using conditional transgenic mice. By replacing aE-catenin with aT-catenin in specific organs, researchers observed that aT-catenin could rescue the lethal phenotype caused by aE-catenin knockout in skin, characterized by keratinocyte hyperproliferation and pre-cancerous lesions. However, the transgenic mice experienced recurrent partial baldness due to issues in hair cycle transition, indicating potential functional discrepancies or insufficient a-catenin levels. The findings provided proof-of-principle for further experiments on a-catenin protein switches in carcinoma models.

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research Eph Receptors and Ephrins: Therapeutic Opportunities

222 citations , October 2014 in “Annual Review of Pharmacology and Toxicology”

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.