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This study reports that five new progesterone derivatives demonstrated inhibitory activity against the 5α-reductase enzyme and binding affinity for the androgen receptor in an in vitro hamster model.

This study reported that newly synthesized phenanthridin-3-one derivatives effectively inhibit human steroid 5-α-reductase.

This review explores the diverse roles of rosemary, covering its nutritional and medicinal uses, cosmetic and pharmaceutical applications, and evaluates various extraction methods, with a focus on sustainable practices and commercial prospects.

This study found that the methanolic heartwood extract of Avicennia marina significantly inhibits 5α-reductase type 1, reducing 5α-DHT production by 52% in a cell-based assay with human hair dermal papilla cells.

In this study, topical application of Tectona grandis seed extracts on albino mice significantly accelerated hair growth initiation time and increased the percentage of hair follicles in the anagenic phase compared to the standard minoxidil treatment.

In this study, amitraz was found to be an effective and well-tolerated treatment for resolving sarcoptic mange in alpacas, demonstrating no relapse over a 10-month follow-up.

This study found that 10,11-dibrominecrebanine (2Br-Cre) and Stephanine demonstrate significant anti-inflammatory and analgesic properties in various experimental models, with 2Br-Cre showing enhanced efficacy over Cre and both compounds potentially mediating their analgesic effects through opioid receptors.

This study constructed a model to predict finasteride's inhibitory activity on 5α-reductase type 2 and calculated that a 1 μM plasma concentration, after 50 mg administration, matches prostate inhibition levels.

In this study, FCE 28260 showed greater potency than finasteride in inhibiting 5α-reductase enzymes and reducing prostate DHT levels in rats.

In this study, all stereoisomers of cyoctol were synthesized and tested, revealing that contrary to initial patent claims, cyoctol does not function as an anti-androgen.

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

This review discusses the phytoconstituents and biological properties of T. orientalis and T. occidentalis, but reports no new clinical results.

This study reported that newly synthesized progesterone derivatives significantly reduced prostate weight in testosterone-treated hamsters, with 5alpha-reductase inhibitory activity dependent on the size of the substituent at C-17.

This study introduced a new method for extracting red mordant dyes from wool fibers that preserved the fibers for further analysis and allowed for spectrophotometric examination of the dyes' absorption curves.

This study identified seven potential enzyme inhibitors from a Polygonum cuspidatum extract using ultrafiltration combined with high-performance liquid chromatography. These compounds showed inhibitory activity against tyrosinase, α-glucosidase, and xanthine oxidase, with most discovered in this extract for the first time.

This study found that finasteride- and dutasteride-loaded iron oxide nanoparticles improved drug penetration in the skin, suggesting they may be promising for topical alopecia therapies.

This study presents a modified method for synthesizing ~1 nm zinc oxide nanoparticles within the pores of SBA-11, maintaining the mesoporous structure without requiring alcohol reflux or basic solution reaction steps.

This study found that elastic liposomes enhanced skin delivery of genistein in haired skin compared to conventional liposomes, but showed decreased effectiveness in hairless skin.

This article describes the synthesis of novel polyamine-modified minoxidil analogs and conjugates to potentially enhance minoxidil's biological activity, selectivity, and water solubility, but reports no new biological results.

This study reports that synthetic carbohydrate receptors effectively inhibit Zika virus infection in cell cultures by blocking early stages of viral entry.

This study introduced a novel nonsteroidal androgen receptor antagonist that effectively controls sebum production in the golden Syrian hamster ear model through targeted follicular delivery.

This study identified two cytochrome P450 enzymes in Avicennia marina leaves that may contribute to the biosynthesis of triterpenoids, potentially responsible for the plant's medicinal properties.

This study demonstrated that lactate dehydrogenase activity is notably high in quiescent hair follicle stem cells within mouse skin using a specific enzymatic activity assay.

This study found that ovine dermal papilla cells exhibit robust aggregation in culture, offering a model to investigate the regulation of hair follicle dermal papilla size.

This study found that trans-3,4'-Dimethyl-3-hydroxyflavanone reduces active TGF-beta2 levels in human keratinocytes, suggesting it may enhance hair growth by suppressing the TGF-beta2 activation pathway.

This study found that the non-steroidal antiandrogen RU58841 increased hair growth rates and promoted hair cycle initiation in balding human scalp grafts on testosterone-conditioned nude mice, indicating a positive effect on hair growth.

This study found that Gelidium corneum, a type of red seaweed, may serve as a promising source of bioactive compounds for skin health, showing photoprotective and healing properties in vitro and antioxidant and stability benefits in vivo when used in dermocosmetic formulations.

This article reviews the potential of inhalation therapy to restore pulmonary elastin fibers in COPD patients and highlights the need for studies to test its feasibility; it reports no new research findings.

This study reported that the n-butanol fraction of Perilla frutescens extract, particularly rosmarinic acid, showed potential for hair regrowth and anti-androgenic activity in male mice, suggesting it as a possible treatment for androgenetic alopecia.

This review highlights the potential of microneedles and nanomedicine in advancing tissue regeneration, emphasizing their innovative, localized, and minimally invasive approaches as promising solutions to current challenges in treating chronic wounds and degenerative diseases.