Trans-3,4'-Dimethyl-3-Hydroxyflavanone, a Hair Growth Enhancing Active Component, Decreases Active Transforming Growth Factor Beta 2 (TGF-Beta2) Through Control of Urokinase-Type Plasminogen Activator (uPA) on the Surface of Keratinocytes

    January 2008 in “ Biological and Pharmaceutical Bulletin ”
    Sasajima Michiyo, Shigeru Moriwaki, Mitsuyuki Hotta, Takashi Kitahara, Yoshinori Takema
    TLDR t-Flavanone may help hair growth by reducing a specific protein's activity in skin cells.
    The study investigated the hair growth enhancing effects of trans-3,4'-Dimethyl-3-hydroxyflavanone (t-flavanone), a synthetic compound effective against male pattern alopecia. t-Flavanone was found to reduce the levels of active transforming growth factor beta 2 (TGF-beta2) in human keratinocytes, without altering the total TGF-beta2 levels. This reduction was linked to the suppression of the TGF-beta2 activation cascade, specifically through decreased activity of urokinase-type plasminogen activator (uPA) on the keratinocyte surface. The findings suggested that t-flavanone's novel mechanism of action could have therapeutic effects on various types of alopecia beyond male pattern alopecia.
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