Trans-3,4'-Dimethyl-3-Hydroxyflavanone, a Hair Growth Enhancing Active Component, Decreases Active Transforming Growth Factor Beta 2 (TGF-Beta2) Through Control of Urokinase-Type Plasminogen Activator (uPA) on the Surface of Keratinocytes

January 2008 in “ Biological and Pharmaceutical Bulletin ”

Sasajima Michiyo, Shigeru Moriwaki, Mitsuyuki Hotta, Takashi Kitahara, Yoshinori Takema

trans-3,4'-Dimethyl-3-hydroxyflavanone t-flavanone male pattern alopecia transforming growth factor beta 2 TGF-beta2 keratinocytes urokinase-type plasminogen activator uPA alopecia male pattern baldness

Studysummary This study found that trans-3,4'-Dimethyl-3-hydroxyflavanone reduces active TGF-beta2 levels in human keratinocytes, suggesting it may enhance hair growth by suppressing the TGF-beta2 activation pathway.

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