Trans-3,4'-Dimethyl-3-Hydroxyflavanone, a Hair Growth Enhancing Active Component, Decreases Active Transforming Growth Factor Beta 2 (TGF-Beta2) Through Control of Urokinase-Type Plasminogen Activator (uPA) on the Surface of Keratinocytes

    January 2008 in “ Biological and Pharmaceutical Bulletin ”
    Sasajima Michiyo, Shigeru Moriwaki, Mitsuyuki Hotta … Yoshinori Takema
    Studysummary This study found that trans-3,4'-Dimethyl-3-hydroxyflavanone reduces active TGF-beta2 levels in human keratinocytes, suggesting it may enhance hair growth by suppressing the TGF-beta2 activation pathway.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jstage.jst.go.jp →
    Discuss this study in the Community →

    Research cited in this study 14

    1. Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla Journal of Investigative Dermatology · 2005
    2. Expression of Truncated Latent TGF-β-Binding Protein Modulates TGF-β Signaling Journal of Cell Science · 2005
    3. Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor Beta 2 Expression Journal of Investigative Dermatology · 2005
    4. Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia Journal of Investigative Dermatology Symposium Proceedings · 2003
    5. Procyanidin B-3, Isolated from Barley and Identified as a Hair-Growth Stimulant, Has the Potential to Counteract Inhibitory Regulation by TGF-β1 Experimental dermatology · 2002
    6. Procyanidin B-2 Extracted from Apples Promotes Hair Growth: A Laboratory Study British journal of dermatology/British journal of dermatology, Supplement · 2002
    7. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    8. Analysis of Apoptotic Cell Death in Human Hair Follicles In Vivo and In Vitro Journal of Investigative Dermatology · 1998
    9. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998
    10. Transforming Growth Factor-β Receptor Type I and Type II Expression During Murine Hair Follicle Development and Cycling Journal of Investigative Dermatology · 1997
    11. Keratinocyte Growth Factor Is an Important Endogenous Mediator of Hair Follicle Growth, Development, and Differentiation. Normalization of the Nu/Nu Follicular Differentiation Defect and Amelioration of Chemotherapy-Induced Alopecia. PubMed · 1995
    12. Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells Biochemical and biophysical research communications · 1995
    13. IL-1 Alpha Inhibits Human Hair Follicle Growth And Hair Fiber Production In Whole-Organ Cultures PubMed · 1993
    14. Human Hair Growth In Vitro Journal of Cell Science · 1990