research Smoothened Antagonists for Hair Inhibition
Two new compounds were found to effectively reduce hair growth in mice.
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research Effect of Citrullus Colocynthis Schrad on Testosterone-Induced Benign Prostatic Hyperplasia
Citrullus colocynthis fruit extract and its compound may help treat enlarged prostate.
![Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase](/images/research/d19df8a7-8de6-4430-8a0d-4ffa1f502985/small/15608.jpg)
research Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase
New compounds were made that effectively block a specific enzyme related to androgen conditions.
research Methodologies to Evaluate the Hair Follicle-Targeted Drug Delivery Provided by Nanoparticles
Nanoparticle-based drug delivery to hair follicles is more effective when tested under conditions that match skin behavior.
research In Vitro Hair Follicle Growth Model for Drug Testing
Researchers developed a new method to test hair growth drugs and found that adult cells are best for hair growth, but the method needs improvement as it didn't create mature hair follicles.
research Self-Emulsifying Drug Delivery Systems (SEDDS): Measuring Energy Dynamics to Determine Thermodynamic and Kinetic Stability
Solidified SEDDS improve drug stability and bioavailability better than liquid SEDDS.
research Studies on the Efficacy of Methyl Esters of N-Alkyl Fatty Acids as Penetration Enhancers
Methyl caprate greatly increases drug absorption through the skin and is better than other enhancers.
research Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing
Nanofiber scaffolds help wounds heal by delivering drugs directly to the injury site.
research New Insights into the Research of Bioactive Compounds from Plant Origins with Nutraceutical and Pharmaceutical Potential
Plant bioactive compounds are important for health and can help prevent various diseases.
research 3D Spheroid Human Dermal Papilla Cell as an Effective Model for the Screening of Hair Growth Promoting Compounds: Examples of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid (TCQA)
3D cell cultures are better for testing hair growth treatments than 2D cultures.
research Development and Evaluation of Crystalline Inclusion Complex of Finasteride Using Electrospraying as a Novel Approach
Created finasteride complex to increase water solubility and drug release.
research Ultra-Performance Liquid Chromatography with Electrospray Ionization Tandem Mass Spectrometry for the Determination of Ketoconazole in Anti-Dandruff Shampoo
The method accurately measures the amount of ketoconazole in anti-dandruff shampoo and cream, and can also be used to monitor the drug in human plasma.
research Thyroid Receptor β: A Promising Target for Developing Novel Anti-Androgenetic Alopecia Drugs
Thyroid receptor β can help develop new drugs to treat hair loss.
research Targeting PrfA From Listeria Monocytogenes: A Computational Drug Repurposing Approach
The research suggests Dutasteride and Solifenacin may be effective against the bacterium causing listeriosis.
research Effects of Natural Herbal Marker Compounds on Human Dermal Papilla Cell Growth Regulation
Four natural compounds were found to promote hair growth effectively.
research Synthesis and Application of Clinically Approved Small-Molecule Drugs Targeting Androgen Receptor
Drugs targeting the Androgen Receptor are effective for treating prostate cancer and other androgen-related conditions.
research Novel Type 1 5a-Reductase Inhibitors With Antiproliferative Potential On LNCaP Cells
New compounds may help treat prostate cancer by reducing cell growth.
research Drug Repurposing: A Promising Approach for Patients With Angina and Non-Obstructive Coronary Artery Disease (ANOCA)
Using existing drugs for new purposes could be a cost-effective way to treat chest pain and non-clogged heart arteries, with some drugs for lung blood pressure showing promise but needing more testing.
research Role of Drug Repurposing in Sustainable Drug Discovery
Drug repurposing speeds up drug development, saves money, and has led to about a third of new drug approvals.
research Active Compounds With Medicinal Potential Found in Maxillariinae Benth. Representatives: A Review
Maxillariinae orchids contain 62 compounds with potential health benefits, including treating skin conditions and diseases like cancer and diabetes.
research Peer Review of Computational Drug Repositioning Based on Side-Effects Mined from Social Media
Reviewers criticized the study for assuming drugs with similar side-effects work the same way and questioned the validity of its findings due to potential biases and data quality issues.
research Chemical Examination of Three Indian Medicinal Plants and Their Hair Growth Evaluation Studies
Three Indian medicinal plant compounds help hair growth.
research Non-Competitive Androgen Receptor Inhibition In Vitro And In Vivo
Two new compounds can block androgen receptor activity in different ways and may lead to new treatments for androgen-related diseases.
research Bullous/Mucous Membrane
High blood pressure drugs often cause skin lupus, stopping the drug usually helps. A vaccine helps prevent genital herpes and HPV-16. More frequent light therapy clears psoriasis faster. No link was found between low iron and chronic hair loss.
research Annotated Patent Selections
The document highlights various patents for new compounds with potential treatments for multiple diseases, including cancer, hormonal disorders, and diabetes.
research 17α-Acetoxy-6-Bromo-16β-Methylpregna-4,6-Diene-3,20-Dione: A New Steroidal Derivative with High Antiandrogenic Activity
A new compound with strong antiandrogenic effects was found, potentially useful for treating conditions like acne and prostate cancer.
research The Effect of Drugs on Hair
Drugs can change hair growth and this is important because it can upset people.
research US Food and Drug Administration Warning Regarding Finasteride and Suicidal Ideation: What Should Urologists Know?
Urologists should screen for mental health issues before and during finasteride treatment.
research Drug Repurposing Against KRAS Mutant G12C: A Machine Learning, Molecular Docking, and Molecular Dynamics Study
Afatinib, neratinib, and zanubrutinib could be effective against KRASG12C-mutant tumors.
research Aging and Immortality: Quasi-Programmed Senescence and Its Pharmacologic Inhibition
The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.