TLDR The research suggests Dutasteride and Solifenacin may be effective against the bacterium causing listeriosis.
The study "Targeting PrfA from Listeria monocytogenes: a computational drug repurposing approach" explores a new method to combat the bacterium Listeria monocytogenes, which causes the life-threatening disease listeriosis. The researchers used a computational approach to screen over 700 FDA-approved drugs against the structure of a key virulence factor in the bacterium, Positive Regulatory Factor A (PrfA). The study identified Dutasteride and Solifenacin as potential inhibitors of PrfA, suggesting they could be effective against Listeria monocytogenes. These drugs are already approved for use in humans for benign prostatic hyperplasia and androgenic alopecia, and urinary incontinence respectively, which could expedite their potential use against listeriosis, especially in the face of multi-drug resistant strains.
27 citations,
March 2017 in “Current Clinical Pharmacology” Dutasteride is becoming a popular hair loss treatment, proving more effective than finasteride with similar side effects.
24 citations,
June 2013 in “Expert opinion on pharmacotherapy” Dutasteride effectively treats benign prostatic hyperplasia but isn't approved for preventing prostate cancer.
December 2024 in “Therapeutic Delivery” Topical dutasteride shows promise for hair loss but needs more research.
November 2013 in “Journal of clinical & experimental dermatology research” Dutasteride can help treat hair loss in both men and women.
December 2022 in “Scholars journal of applied medical sciences” Dutasteride 0.5mg improves hair growth in 78% of people with hair loss, but may cause sexual problems in some.
8 citations,
October 2020 in “Pharmaceutics” Dutasteride-loaded nanoparticles coated with Lauric Acid-Chitosan show promise for treating hair loss due to their controlled release, low toxicity, and potential to stimulate hair growth.
The new dutasteride gel improves hair growth for treating baldness.
October 2006 in “Aging Health” Dutasteride effectively treats benign prostatic obstruction, improves urinary flow, reduces prostate size, and may prevent prostate cancer, but can cause sexual side effects.
