Effects of Natural Herbal Marker Compounds on Human Dermal Papilla Cell Growth Regulation

December 2023

Bu Young Choi

From the encyclopedia

An essential vasodilator with some anti-androgenic effects

a JAK inhibitor for alopecia areata and other autoimmune conditions

Studysummary This study evaluated 32 marker compounds from natural herbal extracts and found that four of them, honokiol, isoalantolactone, broussochalcone A, and 3-deoxysappanone B, can induce hair growth, suggesting a potential natural treatment for hair loss. Our plain-language summary of this paper — not a Tressless recommendation.

The study "Effects of Natural Herbal Marker Compounds on Human Dermal Papilla Cell Growth Regulation" tested 32 natural herbal compounds on human hair follicle dermal papilla cells. The impact on mRNA gene expression and Wnt and JAKs signaling transcription factor activities was evaluated. Seven compounds were found to induce growth equal to or greater than minoxidil or tofacitinib. Four compounds (honokiol, isoalantolactone, broussochalcone A, and 3-deoxysappanone B) were found to scientifically induce hair growth. The study suggests these four compounds could be used to develop a natural product for improving hair loss. The study used a CellTiter-Glo® luminescent cell viability assay kit to determine cell survival, and quantitative reverse transcription PCR (RT-PCR) to analyze gene expression changes.

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