Effects of Natural Herbal Marker Compounds on Human Dermal Papilla Cell Growth Regulation

    December 2023
    Bu Young Choi
    Studysummary This study evaluated 32 marker compounds from natural herbal extracts and found that four of them, honokiol, isoalantolactone, broussochalcone A, and 3-deoxysappanone B, can induce hair growth, suggesting a potential natural treatment for hair loss.
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    Research cited in this study 21

    1. Insights Into Male Androgenetic Alopecia Using Comparative Transcriptome Profiling: Hypoxia-Inducible Factor-1 and Wnt/Beta-Catenin Signalling Pathways British Journal of Dermatology · 2022
    2. Hair Are the Rankings—5-Alpha Reductase Inhibitors and Minoxidil in Male Androgenetic Alopecia JAMA Dermatology · 2022
    3. KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis British Journal of Pharmacology · 2021
    4. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    5. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    6. Costunolide Promotes the Proliferation of Human Hair Follicle Dermal Papilla Cells and Induces Hair Growth in C57BL/6 Mice Journal of Cosmetic Dermatology · 2018
    7. Androgen Modulation of Wnt/β-Catenin Signaling in Androgenetic Alopecia Archives of Dermatological Research · 2018
    8. Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-Analysis Acta dermato-venereologica · 2018
    9. Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2017
    10. Dutasteride in Androgenetic Alopecia: An Update Current Clinical Pharmacology · 2017
    11. JAK Inhibitors in Dermatology: The Promise of a New Drug Class Journal of the American Academy of Dermatology · 2017
    12. Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients Journal of The American Academy of Dermatology · 2016
    13. 3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling Biomolecules & Therapeutics · 2016
    14. The Latest Trends of Treatment for Alopecia Hanbang an'i'bi'in'hu pibu'gwa haghoeji · 2015
    15. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    16. Effect of Ultraviolet Radiation, Smoking, and Nutrition on Hair Current problems in dermatology · 2015
    17. Combination of Herbal Extracts and Platelet-Rich Plasma Induced Dermal Papilla Cell Proliferation: Involvement of ERK and Akt Pathways Journal of Cosmetic Dermatology · 2013
    18. The Hair Cycle Journal of Cell Science · 2006
    19. Positive Lymphocyte Transformation Test in a Patient with Allergic Contact Dermatitis of the Scalp After Short-Term Use of Topical Minoxidil Solution Contact Dermatitis · 2005
    20. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    21. Finasteride Drugs · 1999

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    9. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998