Effects of Natural Herbal Marker Compounds on Human Dermal Papilla Cell Growth Regulation

December 2023

Bu Young Choi

TLDR Four natural compounds were found to promote hair growth effectively.

The study "Effects of Natural Herbal Marker Compounds on Human Dermal Papilla Cell Growth Regulation" tested 32 natural herbal compounds on human hair follicle dermal papilla cells. The impact on mRNA gene expression and Wnt and JAKs signaling transcription factor activities was evaluated. Seven compounds were found to induce growth equal to or greater than minoxidil or tofacitinib. Four compounds (honokiol, isoalantolactone, broussochalcone A, and 3-deoxysappanone B) were found to scientifically induce hair growth. The study suggests these four compounds could be used to develop a natural product for improving hair loss. The study used a CellTiter-Glo® luminescent cell viability assay kit to determine cell survival, and quantitative reverse transcription PCR (RT-PCR) to analyze gene expression changes.

View this study on elabp.org →

Discuss this study in the Community →

Research cited in this study

21 / 21 results

research Insights Into Male Androgenetic Alopecia Using Comparative Transcriptome Profiling: Hypoxia-Inducible Factor-1 and Wnt/Beta-Catenin Signalling Pathways

1 citations, July 2022 in “British Journal of Dermatology”

Targeting specific genes in certain pathways may help treat male pattern baldness.

research Hair Are the Rankings—5-Alpha Reductase Inhibitors and Minoxidil in Male Androgenetic Alopecia

1 citations, February 2022 in “JAMA Dermatology”

Minoxidil and finasteride are FDA-approved treatments for male hair loss, but off-label use of oral minoxidil, dutasteride, and higher doses of finasteride and minoxidil is increasing.

research KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis

13 citations, March 2021 in “British Journal of Pharmacology”

KY19382 helps regrow hair and create new hair follicles.

research Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

86 citations, July 2020 in “International Journal of Molecular Sciences”

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations, May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

research Costunolide Promotes the Proliferation of Human Hair Follicle Dermal Papilla Cells and Induces Hair Growth in C57BL/6 Mice

21 citations, May 2018 in “Journal of Cosmetic Dermatology”

Costunolide helps human hair cells grow and can stimulate hair growth in mice.

research Androgen Modulation of Wnt/β-Catenin Signaling in Androgenetic Alopecia

39 citations, March 2018 in “Archives of Dermatological Research”

Androgens may block hair growth signals, targeting this could treat hair loss.

Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-Analysis

research Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-Analysis

15 citations, January 2018 in “Acta dermato-venereologica”

Finasteride and dutasteride increase sexual dysfunction risk by 1.57 times in male hair loss treatment.

research Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management

102 citations, December 2017 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Restoring hair bulb immune privilege is crucial for managing alopecia areata.

research Dutasteride in Androgenetic Alopecia: An Update

27 citations, March 2017 in “Current Clinical Pharmacology”

Dutasteride is becoming a popular hair loss treatment, proving more effective than finasteride with similar side effects.

research JAK Inhibitors in Dermatology: The Promise of a New Drug Class

355 citations, January 2017 in “Journal of the American Academy of Dermatology”

JAK inhibitors show promise for treating skin conditions like eczema, hair loss, and psoriasis.

research Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients

238 citations, November 2016 in “Journal of The American Academy of Dermatology”

Tofacitinib is effective and safe for severe hair loss, but full regrowth is less likely after 10 years of hair loss.

3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling

research 3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling

26 citations, October 2016 in “Biomolecules & Therapeutics”

3-Deoxysappanchalcone helps human hair cells grow and stimulates hair growth in mice by affecting certain cell signaling pathways.

research The Latest Trends of Treatment for Alopecia

4 citations, November 2015 in “Hanbang an'i'bi'in'hu pibu'gwa haghoeji”

Finasteride, Dutasteride, and Minoxidil are effective for hair growth, while new treatments like laser therapy and PRP show promise with few side effects.

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

159 citations, October 2015 in “Science Advances”

Blocking JAK-STAT signaling can lead to hair growth.

research Effect of Ultraviolet Radiation, Smoking, and Nutrition on Hair

19 citations, January 2015 in “Current problems in dermatology”

Ultraviolet rays damage hair, smoking may cause hair loss, and good nutrition is important for hair health, but genetics mainly decide hair thickness.

Combination of Herbal Extracts and Platelet-Rich Plasma Induced Dermal Papilla Cell Proliferation: Involvement of ERK and Akt Pathways

research Combination of Herbal Extracts and Platelet-Rich Plasma Induced Dermal Papilla Cell Proliferation: Involvement of ERK and Akt Pathways

39 citations, June 2013 in “Journal of Cosmetic Dermatology”

Herbal extracts and platelet-rich plasma together may help increase hair growth by making certain cells grow more, through specific cell growth pathways.

research The Hair Cycle

375 citations, February 2006 in “Journal of Cell Science”

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

Positive Lymphocyte Transformation Test in a Patient with Allergic Contact Dermatitis of the Scalp After Short-Term Use of Topical Minoxidil Solution

research Positive Lymphocyte Transformation Test in a Patient with Allergic Contact Dermatitis of the Scalp After Short-Term Use of Topical Minoxidil Solution

38 citations, June 2005 in “Contact Dermatitis”

Patient had scalp allergy from minoxidil; test helped identify cause and suggest alternative treatments.

research Molecular Mechanisms Regulating Hair Follicle Development

854 citations, February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.

research Finasteride

125 citations, January 1999 in “Drugs”

Finasteride effectively treats baldness but may cause sexual side effects.

Related Research

9 / 9 results

A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia

research A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia

43 citations, July 2018 in “Journal of The European Academy of Dermatology and Venereology”

Finasteride and minoxidil mix works better for hair growth than minoxidil alone, with similar safety.

research The Modern Treatment of Androgenetic Alopecia

February 2017 in “Vestnik dermatologii i venerologii”

Hair loss can be treated with common methods like minoxidil and finasteride, but new potential treatments include growth factors, cytokines, and platelet-rich plasma injections.

research Topical Minoxidil Fortified with Finasteride: Maintenance of Hair Density After Replacing Oral Finasteride

August 2016 in “International journal of scientific research”

Using minoxidil with finasteride in a cream helps maintain hair thickness after stopping oral finasteride.

Combined Treatment with Oral Finasteride and Topical Minoxidil in Male Androgenetic Alopecia: A Randomized and Comparative Study in Chinese Patients

research Combined Treatment with Oral Finasteride and Topical Minoxidil in Male Androgenetic Alopecia: A Randomized and Comparative Study in Chinese Patients

32 citations, June 2015 in “Dermatologic Therapy”

Finasteride and minoxidil together work best for male hair loss.

A New Topical Formulation of Minoxidil and Finasteride Improves Hair Growth in Men with Androgenetic Alopecia